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Updated: Feb 10, 2026
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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
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[Series: Caries prevention in historical perspective. Fluoride].
Nederlands Tijdschrift Voor Tandheelkunde
|May 14, 2018
Summary
Fluoride prevents dental caries by strengthening enamel and inhibiting decalcification. While water fluoridation was once favored, fluoride toothpaste is now recognized as the primary method for caries prevention.
Area of Science:
- Dentistry
- Public Health
- Biochemistry
Background:
- The understanding of fluoride's role in preventing dental caries has evolved significantly since World War II.
- Early theories focused on fluoride incorporation into tooth structure during development.
- Subsequent research highlighted fluoride's topical effects on enamel and plaque.
Purpose of the Study:
- To review the historical development of knowledge regarding fluoride and dental caries prevention.
- To contrast the mechanisms of fluoride action in caries prevention.
- To delineate the shift in recommended public health strategies for caries control.
Main Methods:
- Historical literature review.
- Analysis of scientific consensus shifts over time.
- Comparison of different fluoride delivery mechanisms.
Main Results:
- Initially, fluoride's benefit was attributed to systemic absorption during tooth formation, enhancing enamel resistance.
- Later findings demonstrated that topical fluoride in dental plaque inhibits enamel demineralization.
- The perceived effectiveness of water fluoridation has diminished relative to topical fluoride application.
Conclusions:
- Fluoride's caries prevention mechanism is multifaceted, involving both developmental and topical effects.
- Current public health recommendations emphasize topical fluoride application, particularly through toothpaste, as the most effective strategy.
- The understanding of fluoride's impact on dental health continues to inform preventive strategies.
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