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Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
Published on: October 26, 2016
Balloon-expandable stents for recoarctation of the aorta in small children. Two centre experience
K Gendera1, P Ewert1, D Tanase1
1Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich, Technische Universität München, Germany.
Insights
Stent implantation is a successful treatment for very young patients with aortic coarctation (CoA) and re-coarctation (re-CoA), showing immediate hemodynamic improvement. Further interventions may be needed for aortic growth.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Interventional Cardiology
Background:
- Surgery is the primary treatment for native aortic coarctation (CoA) in children.
- Re-coarctation (re-CoA) surgery carries higher risks, and some native CoA cases have surgical contraindications.
- This study evaluates stent implantation for these challenging pediatric cases.
Purpose of the Study:
- To assess the efficacy and safety of percutaneous stent implantation in very young patients with native aortic coarctation and re-coarctation.
- To evaluate the immediate hemodynamic outcomes and complications associated with the procedure.
Main Methods:
- A total of 34 patients (median age 6.5 months, median weight 6.2 kg) underwent stent implantation between 2006 and 2017.
- Patients included those with re-CoA (31) and native CoA (3) with surgical contraindications.
- Balloon-expandable stents were used, with inclusion criteria of age < 3 years and weight < 16 kg.
Main Results:
- All procedures were technically successful, with a significant reduction in the peak systolic pressure gradient (31 to 0 mmHg, p < 0.001).
- The minimal diameter of the aorta significantly increased (3 mm to 7 mm, p < 0.001).
- No serious complications occurred; however, 29% required re-dilatation and 6% needed re-stenting during a median follow-up of 12.5 months.
Conclusions:
- Percutaneous stent implantation is a viable and successful option for very young patients with re-CoA and selected native CoA cases.
- The procedure yields good immediate hemodynamic results, but requires ongoing management for aortic growth.
- Further interventions like re-dilatation and re-stenting are necessary to achieve adult aortic dimensions.
Background:
In young patients with native aortic coarctation (CoA), the management of choice is surgery. However, in re-coarctation (re-CoA) surgery is associated with increased morbidity and even mortality. Some children with native CoA present relative contraindications for surgery.
Methods:
From 2006 to 2017, thirty-four patients (male n = 20; 59%) from two centres with re-CoA (31) and native CoA (3) were managed by stent implantation with premounted balloon expandable stents. Inclusion criteria were age < 3 years and >1 month, weight < 16 kg. Median age was 6,5 months (min. 1; max. 34 months), median weight 6,2 kg (min. 3,7; max. 16 kg). Thirteen patients (38%) had Re-CoA and hypoplastic left heart syndrome (HLHS). In three patients (9%) the native CoA was stented due to contraindications for surgical treatment.
Results:
All procedures were successful. The median peak invasive systolic pressure gradient declined from 31 mm Hg (max. 118; min. 4) to 0 mm Hg (max. 32; min.-7) (p < 0.001). The median minimal diameter of the narrowed segment of aorta increased from 3 mm (max. 6,9; min. 1,0) to 7 mm (max. 11,5; min. 3,5) (p < 0.001). There were no serious complications. The median follow-up time was 12,5 months (max. 88; min. 0 month). During this time ten patients (29%) required re-dilatation and two of them re-stenting.
Conclusion:
Percutaneous stent implantation for Re-CoA and in selected patients for native CoA can be performed successfully in very young patients with a good immediate hemodynamical result. However, repeated stent angioplasties and further on interventional 'opening' of the stent is necessary to augment the aorta to adult size.
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