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Related Experiment Video

Updated: Feb 10, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Default Mode Network Oscillatory Coupling Is Increased Following Concussion.

Benjamin T Dunkley^1,2,3, Karolina Urban⁴, Leodante Da Costa⁵

¹Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada.

Frontiers in Neurology

|May 15, 2018

Summary

This summary is machine-generated.

A single concussion can disrupt brain networks, increasing connectivity in the default mode network (DMN) and motor networks (MOTs). This altered brain connectivity is linked to persistent concussion symptoms.

Keywords:

concussion functional connectivity magnetoencephalography mild traumatic brain injury neural oscillations resting-state synchrony

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Area of Science:

Neuroscience
Brain Injury Research
Cognitive Science

Background:

Concussion, a mild traumatic brain injury, can cause lasting functional brain alterations.
Cognitive complaints after concussion may stem from deficits in brain activity and communication.
Intrinsic Connectivity Networks (ICNs) are specialized resting brain networks crucial for function.

Purpose of the Study:

To investigate the impact of concussion on neurophysiological and functionally specialized resting brain networks.
To assess alterations in intrinsic connectivity networks (ICNs) following concussion using magnetoencephalography (MEG).
To correlate observed neurophysiological changes with concussion-related symptoms.

Main Methods:

Magnetoencephalography (MEG) was used to assess neurophysiological connectivity in 40 males (20 with concussion, 20 controls).
Regions-of-interest within ICNs were defined, and functional connectivity was measured via band-limited amplitude envelope covariations.
Intra-network connectivity was compared between groups and correlated with symptom severity, controlling for comorbidities.

Main Results:

The concussion group exhibited increased resting spectral connectivity in the default mode network (DMN) and motor networks (MOTs) across alpha to gamma frequency ranges.
These connectivity differences were independent of power spectrum density within the ICNs.
Increased DMN connectivity was significantly associated with symptoms, even after accounting for comorbidities like depression, anxiety, and ADHD.

Conclusions:

Even a single concussion can perturb the intrinsic coupling of specialized brain networks, particularly the DMN.
Altered intrinsic connectivity, especially within the DMN, may underlie persistent and widespread concussion symptomatology.
These findings highlight the potential of MEG in understanding concussion-related functional brain changes.