Related Experiment Video

Updated: Feb 10, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

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Integrating the DNA damage and protein stress responses during cancer development and treatment

Vassilis G Gorgoulis1,2,3, Dafni-Eleftheria Pefani4, Ioannis S Pateras1

  • 1Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

The Journal of Pathology
|May 15, 2018
PubMed

Insights

Cellular stress response pathways, including genome and proteome damage repair, are crucial for homeostasis. Their dysfunction is linked to aging and cancer, offering therapeutic targets.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Cancer Research

Background:

  • Cells possess stress response modules for homeostasis.
  • Genome and proteome damage response pathways are key defensive networks.
  • Deregulation of these pathways is linked to aging and cancer.

Purpose of the Study:

  • To review the structure and function of genome and proteome damage response pathways.
  • To explore their crosstalk and link to cancer predisposition.
  • To highlight the role of oncogene-induced DNA damage in cancer development.

Main Methods:

  • Literature review of cellular stress response mechanisms.
  • Analysis of pathway interactions and their role in oncogenesis.
  • Discussion of therapeutic strategies targeting pathway alterations.

Main Results:

  • Detailed overview of genome and proteome damage response pathways.
  • Elucidation of functional crosstalk between these pathways.
  • Identification of oncogene-induced DNA damage as a driver of cancer hallmarks.

Conclusions:

  • Dysregulated stress response pathways contribute to cancer.
  • Understanding these pathways offers novel therapeutic opportunities.
  • Targeting cancer-related alterations in these pathways can lead to effective treatments.
Keywords:
DNA damage responsecancerhomeostasisoncogenesproteome damage responsereplication stressstress responsetumor suppressors

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