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Cardiac function in children with premature ventricular contractions: the effect of omega-3 polyunsaturated fatty

Taliha Oner1, Rahmi Ozdemir2, Onder Doksöz2

  • 11SisliEtfal Training and Research Hospital,Department of Pediatric Cardiology,Sisli,Istanbul,Turkey.

Cardiology in the Young
|May 16, 2018
PubMed

Insights

Premature ventricular contractions in children can impair heart function. Omega-3 fatty acid supplementation showed potential to improve cardiac performance in a pediatric study.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Research
  • Nutritional Supplementation

Background:

  • Premature ventricular contractions (PVCs) are generally considered benign in children with normal heart structure.
  • However, PVCs can potentially lead to reversible cardiomyopathy.
  • Omega-3 polyunsaturated fatty acids possess known anti-arrhythmic properties.

Purpose of the Study:

  • To assess left ventricular function in children diagnosed with PVCs and normal cardiac anatomy.
  • To investigate the therapeutic effect of omega-3 fatty acid supplementation on left ventricular function in this pediatric population.

Main Methods:

  • A prospective trial involving 25 children with PVCs (>2% on 24-hour Holter) and 30 healthy controls.
  • Evaluations included electrocardiography, M-mode echocardiography, and myocardial performance index.
  • PVC group received 1g/day omega-3 fatty acids for 3 months, followed by repeat assessments.

Main Results:

  • Children with PVCs exhibited significantly reduced fractional shortening compared to controls.
  • The myocardial performance index was notably decreased in the PVC group.
  • Omega-3 supplementation led to a significant reduction in mean heart rate and PVC percentage.

Conclusions:

  • Pediatric PVCs can be associated with systolic cardiac dysfunction.
  • Omega-3 fatty acid supplementation may serve as a beneficial intervention to improve cardiac function in children with PVCs.
  • This study represents the first investigation into the role of omega-3s for treating PVCs in children.
Abstract

Keywords:
Premature ventricular contractionscardiac functionchildrenomega-3 PUFA

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