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Updated: Feb 10, 2026

Imaging FITC-dextran as a Reporter for Regulated Exocytosis
Published on: June 20, 2018
Actin Remodeling in Regulated Exocytosis: Toward a Mesoscopic View
Pin Li1, Adekunle T Bademosi2, Jincai Luo3
1Laboratory of Vascular Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing 100871, China; Joint first authors.
Abstract:
Cellular communication relies on fusion of secretory vesicles with the plasma membrane, following dynamic events that change the micro- and nanoscale environment of the approaching vesicles in the vicinity of docking sites. Visualization of fine cortical actin network structures and their interactions with vesicle and plasma membrane has recently been facilitated by the development of new imaging technologies. Consequently, a greater understanding is emerging of the role of the cortical actin network on controlling secretory vesicles as they undergo docking, priming, and fusion in exocytic hot spots. In this review, we propose a mechanistic framework underpinning the mesoscopic properties of the cortical actin and discuss how molecular coupling of these pleiotropic effects orchestrate every single step of regulated exocytosis.
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