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Synthetic studies on daphniglaucins
Yuanyou Qiu1, Jiaxin Zhong, Shan Du
1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, China. shgao@chem.ecnu.edu.cn.
Abstract:
The synthetic approach to the core framework of daphniglaucin-type Daphniphyllum alkaloids is described herein. The B-C ring was constructed via a Rh-catalyzed [3+2] cycloaddition. Continuous quaternary centers were installed through [3+2] cycloaddition and alkylation. The attempt to build the A-D ring motif using dipolar cycloaddition of azomethine ylides was extensively investigated.
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