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[Effect of artery pulse on the osteonal interstitial fluid flow behavior]
Xiaogang Wu1, Ningning Wang1, Haipeng Cen1
1Shanxi Key Lab. of Material Strength & Structural Impact, College of Mechanics, Taiyuan University of Technology, Taiyuan 030024, P.R.China.
Summary
Blood pressure oscillation significantly increases interstitial fluid pressure within bone tissue, impacting cell metabolism. Fluid velocity remained largely unchanged, suggesting pressure changes are key to understanding bone fluid dynamics.
Area of Science:
- Biomedical Engineering
- Skeletal Biology
- Fluid Dynamics
Context:
- Bone tissue contains blood and interstitial fluid, crucial for cell metabolism.
- Osteonal interstitial fluid seepage is a key area of research.
- Understanding fluid dynamics in bone is vital for skeletal health.
Purpose:
- To investigate the effect of blood pressure oscillation on osteonal interstitial fluid seepage.
- To compare fluid flow behavior in finite element osteon models with and without blood pressure oscillation.
Summary:
- Finite element models simulated osteon fluid flow under axial loading, incorporating blood pressure oscillation.
- Results showed increased interstitial fluid pressure with blood pressure oscillation.
- Fluid velocity showed minimal changes, while pressure amplitude was the primary driver of pressure increase.
Impact:
- The study provides insights into bone mechanotransduction and electromechanotransduction mechanisms.
- The developed finite element model can analyze poroelastic behaviors under complex loading conditions.
- Findings enhance understanding of how circulatory dynamics influence bone microenvironment.
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