Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Transformation01:33

Bacterial Transformation

60.1K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
60.1K
Transformers01:26

Transformers

1.9K
A device that transforms voltages from one value to another using induction is called a transformer. A transformer consists of two separate coils, or windings, wrapped around the same soft iron core. However, they are electrically insulated from each other.
The iron core has a substantial relative permeability. Therefore, the magnetic field lines generated due to the current in one winding are almost entirely confined within the core, such that the same magnetic flux permeates each turn of both...
1.9K
Transformation01:26

Transformation

1.1K
Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
1.1K
Transformations of Functions I01:29

Transformations of Functions I

204
A function's graph can be modified by changing its position or size without altering its overall shape. These transformations allow the graph to be moved across the coordinate plane while preserving its pattern and structure. One of the most common transformations is shifting, which repositions the graph without distorting it.When the output of a function is adjusted by adding or subtracting a constant, the graph shifts vertically. A positive value moves the graph upward, while a negative value...
204
The Ideal Transformer01:26

The Ideal Transformer

1.4K
In single-phase two-winding transformers, two windings are coiled around a magnetic core characterized by cross-sectional area A and magnetic permeability μ. A phasor current i1 enters the left winding while i2 exits the right winding, establishing the fundamental working of the transformer through electromagnetic principles.
Ampere's Law forms the basis of understanding the magnetic field within the transformer. It states that the integral of the magnetic field intensity's tangential...
1.4K
Properties of the z-Transform II01:16

Properties of the z-Transform II

441
The property of Accumulation in signal processing is derived by analyzing the accumulated sum of a discrete-time signal and using the time-shifting property to determine its z-transform. This principle reveals that the z-transform of the summed signal is related to the z-transform of the original signal by a multiplicative factor.
Moreover, the convolution property indicates that the convolution of two signals in the time domain corresponds to the product of their z-transforms in the frequency...
441

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ANNalog: generation of MedChem-similar molecules.

Journal of cheminformatics·2026
Same author

Off the beaten (catalytic) path: Charting the mechanistic space of enzyme reactions.

The Journal of chemical physics·2025
Same author

Measuring catalytic mechanism similarity - a new approach to study enzyme function and evolution.

The FEBS journal·2025
Same author

A structural perspective on enzymes and their catalytic mechanisms.

Current opinion in structural biology·2025
Same author

Paradigms of convergent evolution in enzymes.

The FEBS journal·2024
Same author

Enzyme function and evolution through the lens of bioinformatics.

The Biochemical journal·2023

Related Experiment Video

Updated: Feb 10, 2026

An Experimental Protocol for Studying Mineral Effects on Organic Hydrothermal Transformations
06:50

An Experimental Protocol for Studying Mineral Effects on Organic Hydrothermal Transformations

Published on: August 8, 2018

6.0K

Transform-MinER: transforming molecules in enzyme reactions.

Jonathan D Tyzack1, Antonio J M Ribeiro1, Neera Borkakoti1

  • 1EMBL-EBI, Wellcome Genome Campus, Cambridge, UK.

Bioinformatics (Oxford, England)
|May 16, 2018
PubMed
Summary

This study introduces Transform Molecules in Enzyme Reactions, a tool to identify native enzyme reactions for synthetic biology. It aids enzyme design and directed evolution by finding similar enzymes for desired molecular transformations.

More Related Videos

Floral-Dip Transformation of Flax Linum usitatissimum to Generate Transgenic Progenies with a High Transformation Rate
08:49

Floral-Dip Transformation of Flax Linum usitatissimum to Generate Transgenic Progenies with a High Transformation Rate

Published on: December 19, 2014

30.0K
Genomic Transformation of the Picoeukaryote Ostreococcus tauri
10:45

Genomic Transformation of the Picoeukaryote Ostreococcus tauri

Published on: July 13, 2012

16.2K

Related Experiment Videos

Last Updated: Feb 10, 2026

An Experimental Protocol for Studying Mineral Effects on Organic Hydrothermal Transformations
06:50

An Experimental Protocol for Studying Mineral Effects on Organic Hydrothermal Transformations

Published on: August 8, 2018

6.0K
Floral-Dip Transformation of Flax Linum usitatissimum to Generate Transgenic Progenies with a High Transformation Rate
08:49

Floral-Dip Transformation of Flax Linum usitatissimum to Generate Transgenic Progenies with a High Transformation Rate

Published on: December 19, 2014

30.0K
Genomic Transformation of the Picoeukaryote Ostreococcus tauri
10:45

Genomic Transformation of the Picoeukaryote Ostreococcus tauri

Published on: July 13, 2012

16.2K

Area of Science:

  • Synthetic biology
  • Enzyme engineering
  • Computational chemistry

Background:

  • Developing novel enzymes is a key goal in synthetic biology for generating new products.
  • Identifying suitable starting enzymes for enzyme design and directed evolution is challenging, often requiring extensive manual effort.

Purpose of the Study:

  • To present an online computational tool, Transform Molecules in Enzyme Reactions, to streamline the identification of enzymes for synthetic biology applications.
  • To assist researchers in enzyme design and directed evolution by highlighting relevant native enzyme reactions.

Main Methods:

  • The Transform Molecules in Enzyme Reactions tool accepts query substrate molecules and transforms them into products using known enzyme reactions.
  • It identifies the most similar native enzyme reactions corresponding to the queried molecular transformations.

Main Results:

  • The tool successfully transforms query substrate molecules into products via enzyme reactions.
  • It provides a ranked list of similar native enzyme reactions, facilitating the selection of enzymes for further investigation.

Conclusions:

  • Transform Molecules in Enzyme Reactions offers a valuable computational approach to accelerate enzyme discovery for synthetic biology.
  • The tool aids in enzyme design and directed evolution by efficiently linking desired molecular transformations to existing enzymatic machinery.