Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

48.4K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.4K
Convergent Evolution01:54

Convergent Evolution

33.1K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
33.1K
Eukaryotic Evolution01:24

Eukaryotic Evolution

42.3K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
42.3K
Synteny and Evolution02:31

Synteny and Evolution

3.8K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.8K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

3.7K
3.7K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

8.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TranDep: a transcriptomics atlas of depression.

Molecular psychiatry·2026
Same author

ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy.

NPJ digital medicine·2026
Same author

Mitochondria limit coenzyme Q export under cholesterol biosynthetic stress.

The Journal of cell biology·2026
Same author

Variations in DNA Methylation Are Landmarks of Freshwater Adaptation in Three-Spined Sticklebacks.

International journal of molecular sciences·2026
Same author

Protocol for identifying cellular reprogramming minimal networks using combinatorial transcription factor screening.

STAR protocols·2026
Same author

Comparative analysis of milk and brain fatty acids reveals human-specific signatures in brain development.

Communications biology·2026

Related Experiment Video

Updated: Feb 10, 2026

Shotgun Lipidomics of Rodent Tissues
11:46

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

2.7K

Lipidome Evolution in Mammalian Tissues.

Ekaterina Khrameeva1,2, Ilia Kurochkin1, Katarzyna Bozek3

  • 1Center for Data-Intensive Biomedicine and Biotechnology, Skolkovo Institute of Science and Technology, Moscow, Russia.

Molecular Biology and Evolution
|May 16, 2018
PubMed
Summary
This summary is machine-generated.

Lipid evolution differs across tissues, with most changes being species-specific, not gradual. Human brains show unique lipid profiles linked to cognitive pathways.

More Related Videos

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
06:48

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

Published on: May 31, 2020

6.3K
Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

4.0K

Related Experiment Videos

Last Updated: Feb 10, 2026

Shotgun Lipidomics of Rodent Tissues
11:46

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

2.7K
On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
06:48

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

Published on: May 31, 2020

6.3K
Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

4.0K

Area of Science:

  • Evolutionary biology
  • Lipidomics
  • Comparative genomics

Background:

  • Lipids are vital for cell structure and function.
  • The evolutionary trajectory of lipid composition across diverse tissues remains largely unexplored.
  • Understanding lipidome evolution provides insights into species adaptation and function.

Purpose of the Study:

  • To investigate the evolutionary patterns of lipidome composition across six tissues in primates, rodents, and bats.
  • To identify conserved versus species-specific lipid evolution.
  • To explore the functional implications of unique lipid features in humans.

Main Methods:

  • Large-scale lipidomic analysis of six tissues from 32 species.
  • Comparative analysis of lipidome evolution against gene sequence and expression evolution.
  • Phylogenetic analysis to track lipid composition changes.

Main Results:

  • Less than 2% of the lipidome evolves in proportion to phylogenetic distance; these conserved lipids are functionally related.
  • Significant species-specific differences in lipidome composition were observed.
  • Humans exhibit the most substantial species-specific lipidome variations, particularly in the brain cortex.
  • Unique human lipid features in the brain cortex are associated with pathways implicated in cognitive disorders.

Conclusions:

  • Lipidome evolution is largely driven by species-specific adaptations rather than gradual phylogenetic changes.
  • Conserved lipids play fundamental roles across tissues and species.
  • Human-specific lipid alterations, especially in the brain, may underlie unique cognitive functions or disorders.