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Updated: Feb 10, 2026

Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets
Published on: July 7, 2010
Genome-wide association analysis identifies a meningioma risk locus at 11p15.5
Elizabeth B Claus1,2, Alex J Cornish3, Peter Broderick3
1School of Public Health, Yale University, New Haven, Connecticut, USA.
Background:
Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31.
Methods:
To identify a susceptibility locus for meningioma, we conducted a meta-analysis of 2 GWAS, imputed using a merged reference panel from the 1000 Genomes Project and UK10K data, with validation in 2 independent sample series totaling 2138 cases and 12081 controls.
Results:
We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges.
Conclusions:
This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.
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