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Updated: Feb 10, 2026
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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
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Ragweed sublingual tablet immunotherapy: part II - practical considerations and pertinent issues.
Oliver Pfaar1,2, Peter Socrates Creticos3,4
1Department of Otorhinolaryngology, Head & Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Immunotherapy
|May 17, 2018
Summary
Sublingual allergen immunotherapy (SLIT) tablets are effective and safe for treating ragweed allergies. This review covers practical considerations for prescribing SLIT ragweed tablets for patients with allergic rhinoconjunctivitis or asthma.
Area of Science:
- Allergy and Immunology
- Pharmacology
- Respiratory Medicine
Background:
- Sublingual allergen immunotherapy (SLIT) is an established treatment for respiratory allergies.
- SLIT ragweed tablets received FDA marketing authorization in 2014 for adult use.
- Clinical trials and real-world data support the efficacy and safety of SLIT ragweed tablets.
Purpose of the Study:
- To review practical considerations for SLIT ragweed tablet therapy.
- To address clinical questions for practitioners before and during treatment.
- To provide guidance on the use of SLIT ragweed tablets.
Main Methods:
- Review of clinical documentation for SLIT ragweed tablets.
- Analysis of pivotal multicenter Phase II and III trials.
- Evaluation of post-registration real-life experience.
Main Results:
- SLIT ragweed tablets are recommended as an efficacious and safe treatment option.
- The treatment offers disease-modifying potential when indicated and performed correctly.
- Practical issues require consideration for optimal patient management.
Conclusions:
- SLIT ragweed tablets are a viable treatment for allergic rhinoconjunctivitis and asthma.
- Practitioners should carefully consider clinical questions prior to initiating therapy.
- Adherence to proper indication and performance ensures treatment success.
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