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New insights from the widening homogeneity perspective to target intratumor heterogeneity

Mengying Tong1, Ziqian Deng1, Xiaolong Zhang1

  • 1Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, 116044, Liaoning, P.R. China.

Cancer Communications (London, England)
|May 17, 2018
PubMed

Insights

Precision medicine faces challenges from intratumor heterogeneity in cancer. This study proposes a novel "homogenization" strategy using iatrogenic evolutionary selection to overcome these limitations and improve cancer treatment.

Area of Science:

  • Oncology
  • Genetics
  • Evolutionary Biology

Background:

  • Precision medicine offers tailored cancer treatments.
  • Intratumor heterogeneity limits the effectiveness of current precision medicine approaches.
  • Targeting cancer's complexity requires innovative therapeutic strategies.

Purpose of the Study:

  • To review current methods for addressing intratumor heterogeneity in cancer.
  • To propose a novel theoretical strategy for targeting intratumor heterogeneity.
  • To explore the potential of iatrogenic evolutionary selection in cancer therapy.

Main Methods:

  • Literature review of precision medicine and intratumor heterogeneity.
  • Theoretical framework development for a "homogenization" strategy.
  • Analysis of iatrogenic evolutionary selection principles.

Main Results:

  • Current approaches to targeting intratumor heterogeneity have limitations.
  • A theoretical "homogenization" strategy shows promise.
  • Iatrogenic evolutionary selection offers a new angle for therapeutic intervention.

Conclusions:

  • Intratumor heterogeneity remains a significant hurdle in precision cancer medicine.
  • A "homogenization" approach based on evolutionary principles could enhance therapeutic outcomes.
  • Further research into iatrogenic evolutionary selection is warranted for cancer treatment development.
Keywords:
Acquired drug resistanceHomogenizationIntratumor heterogeneityPlasticityPrecision medicine

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