The development of a reference database with the Topcon 3D OCT-1 Maestro

Area of Science:

• Ophthalmology
• Medical Imaging
• Retinal Imaging

Background:

• Spectral domain optical coherence tomography (OCT) is crucial for retinal imaging.
• Establishing normative data is essential for accurate diagnosis and disease monitoring.
• New OCT devices require validation with comprehensive reference databases.

Purpose of the Study:

• To determine the range of retinal thickness measurements using the Topcon Maestro 3D OCT device.
• To compare measurements obtained with two different scan settings (12x9 mm and 6x6 mm).
• To establish reference percentiles for key retinal parameters for discrimination purposes.

Main Methods:

• Prospective, multicenter cohort study across 7 US clinical sites.
• Inclusion of healthy volunteers confirmed by comprehensive ophthalmological examination.
• Measurement of macula full retinal thickness, ganglion cell + inner plexiform layer (GCL + IPL), ganglion cell complex (GCC), and circumpapillary retinal nerve fiber layer (cpRNFL) thickness.

Main Results:

• Data from 399 eyes of 399 healthy subjects were analyzed.
• Mean foveal thickness ranged from 234.0 to 237.1 μm, GCL + IPL from 71.4 to 71.7 μm, GCC from 105.9 to 106.7 μm, and cpRNFL from 104.0 to 104.7 μm.
• Measurements showed consistency between the 12x9 mm and 6x6 mm scan settings.

Conclusions:

• The Topcon 3D OCT-1 Maestro provides normal thickness values comparable to other OCT devices.
• Established 1st, 5th, 95th, and 99th percentile reference limits are valuable for quantitative comparison.
• These reference limits facilitate the discrimination of healthy retinal parameters (cpRNFL and macula) against a database of known healthy subjects.