Improving adherence to gout therapy: an expert review

Area of Science:

• Rheumatology
• Pharmacology
• Public Health

Background:

• Gout is a prevalent inflammatory arthritis with significant global health and economic burdens.
• Poor patient adherence to urate-lowering therapies (ULT) is a major challenge, affecting treatment efficacy.
• Gout comorbidities and mortality risk underscore the importance of effective ULT adherence.

Purpose of the Study:

• To review factors influencing adherence to urate-lowering therapies (ULT) in gout patients.
• To aid healthcare providers in understanding and addressing ULT adherence barriers.
• To inform strategies for improving gout patient outcomes through enhanced adherence.

Main Methods:

• Literature review focusing on factors affecting medication adherence in gout.
• Analysis of treatment-, patient-, and physician-related barriers to ULT adherence.
• Exploration of interventions aimed at improving adherence.

Main Results:

• Patient adherence to ULT for gout is notably low, ranging from 20% to 70%.
• Adherence is influenced by complex, multidimensional factors including patient, treatment, and physician elements.
• Various interventions targeting healthcare professionals and patients are under investigation.

Conclusions:

• Addressing the multidimensional nature of ULT non-adherence is crucial for effective gout management.
• Enhanced provider awareness of 'treat-to-target' strategies can improve patient outcomes.
• Empowering patients in self-management is vital for long-term gout control.