Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

281
Body:Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
281
Robbers Cave04:49

Robbers Cave

14.9K
During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension...
14.9K
Filtration and Urine Formation01:32

Filtration and Urine Formation

53.8K
The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
53.8K
Social Traps01:41

Social Traps

26.9K
Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
26.9K
Neural Regulation01:37

Neural Regulation

43.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.5K
Hormonal Regulation01:40

Hormonal Regulation

48.3K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-World Analysis of Initial Clinical Response and Future Outcomes Among Patients with Rheumatoid Arthritis Initiating and Remaining on a First-Line Tumor Necrosis Factor Inhibitor in the United States.

Rheumatology and therapy·2025
Same author

Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension study.

RMD open·2025
Same author

Durable control of psoriatic arthritis with guselkumab across domains and patient characteristics: post hoc analysis of a phase 3 study.

Clinical rheumatology·2024
Same author

Upadacitinib in Rheumatoid Arthritis and Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs: Efficacy and Safety Through 5 Years (SELECT-NEXT).

The Journal of rheumatology·2024
Same author

Improvements in Patient-Reported Outcomes Through Six Months of Guselkumab Treatment in Patients With Active Psoriatic Arthritis: Real-World Data From the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry.

ACR open rheumatology·2024
Same author

Efficacy and safety of tofacitinib in patients with rheumatoid arthritis by previous treatment: post hoc analysis of phase II/III trials.

Arthritis research & therapy·2023
Same journal

Diagnostic Performance of Red Cell Distribution Width in Adult Iraqi Patients with Ankylosing Spondylitis.

Arthritis·2018
Same journal

Burden of Depression among Working-Age Adults with Rheumatoid Arthritis.

Arthritis·2018
Same journal

Physical Examination Tools Used to Identify Swollen and Tender Lower Limb Joints in Juvenile Idiopathic Arthritis: A Scoping Review.

Arthritis·2018
Same journal

Education and Social Support as Key Factors in Osteoarthritis Management Programs: A Scoping Review.

Arthritis·2018
Same journal

Reliability and Construct Validity of the SENS Motion® Activity Measurement System as a Tool to Detect Sedentary Behaviour in Patients with Knee Osteoarthritis.

Arthritis·2018
Same journal

Confidence amongst Multidisciplinary Professionals in Managing Paediatric Rheumatic Disease in Australia.

Arthritis·2018
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
07:25

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

Published on: May 4, 2017

18.3K

Biosimilars Have Arrived: Rituximab.

Maria Greenwald1, John Tesser2, K Lea Sewell3

  • 1Desert Medical Advances, Palm Desert, CA, USA.

Arthritis
|May 17, 2018
PubMed
Summary
This summary is machine-generated.

Rituximab biosimilars are highly similar to the original biologic, with no clinically meaningful differences in safety or efficacy. Several rituximab biosimilars are in development and expected to play a role in treating inflammatory diseases.

More Related Videos

Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies
09:54

Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies

Published on: May 22, 2020

3.9K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.0K

Related Experiment Videos

Last Updated: Feb 10, 2026

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
07:25

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

Published on: May 4, 2017

18.3K
Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies
09:54

Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies

Published on: May 22, 2020

3.9K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.0K

Area of Science:

  • Immunology and pharmacology
  • Biopharmaceutical development
  • Regulatory science

Background:

  • Biologic rituximab patent expiry leads to biosimilar development.
  • Biosimilars require rigorous evaluation for similarity to originator biologics.
  • Understanding biosimilar interchangeability is crucial for patient outcomes.

Purpose of the Study:

  • Analyze rituximab properties and benefits in inflammatory diseases.
  • Review biosimilar development, approval processes, and potential benefits.
  • Assess the role of rituximab biosimilars in patient care.

Main Methods:

  • Searched PubMed and ClinicalTrials.gov for "biosimilar" and "rituximab".
  • Screened regulatory and pharmaceutical company web pages for biosimilar development.
  • Analyzed data on biosimilar guidelines and comparative clinical development.

Main Results:

  • Six rituximab biosimilar candidates are in comparative clinical development.
  • Two rituximab biosimilars have been approved in the European Union.
  • Rituximab biosimilars are anticipated to be used in treating inflammatory conditions.

Conclusions:

  • Rituximab biosimilars demonstrate high similarity to the originator biologic.
  • Rigorous evaluation ensures biosimilar safety, efficacy, and potency.
  • Rituximab biosimilars are expected to expand treatment options for inflammatory diseases like rheumatoid arthritis.