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The Benefits of Exercise on Structural and Functional Plasticity in the Rodent Hippocampus of Different Disease

Anna R Patten¹, Suk Yu Yau¹, Christine J Fontaine¹

¹Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada.

Brain Plasticity (Amsterdam, Netherlands)

|May 17, 2018

Abstract:

In this review, the benefits of physical exercise on structural and functional plasticity in the hippocampus are discussed. The evidence is clear that voluntary exercise in rats and mice can lead to increases in hippocampal neurogenesis and enhanced synaptic plasticity which ultimately result in improved performance in hippocampal-dependent tasks. Furthermore, in models of neurological disorders, including fetal alcohol spectrum disorders, traumatic brain injury, stroke, and neurodegenerative disorders including Alzheimer's, Parkinson's and Huntington's disease exercise can also elicit beneficial effects on hippocampal function. Ultimately this review highlights the multiple benefits of exercise on hippocampal function in both the healthy and the diseased brain.

Keywords:

Cornu Ammonis Exercise behaviour dentate gyrus hippocampus neurogenesis synaptic plasticity

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