Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Contact Angle01:13

Contact Angle

23.7K
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
23.7K
Contact-dependent Signaling01:19

Contact-dependent Signaling

47.6K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
47.6K
Second Order systems II01:18

Second Order systems II

412
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
412
First Order Systems01:21

First Order Systems

434
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
434
Second Order systems I01:20

Second Order systems I

616
A servo system exemplifies a second-order system, featuring a proportional controller and load elements that ensure the output position aligns with the input position. The relationship between these components is described by a second-order differential equation. Applying the Laplace transform under zero initial conditions yields the transfer function, showing how inputs are converted to outputs in the system.
By reinterpreting the system, one can derive the closed-loop transfer function, which...
616
Thermodynamic Systems01:06

Thermodynamic Systems

8.3K
A thermodynamic system is a set of objects whose thermodynamic properties are of interest. The system is considered to be embedded in its surroundings or the environment. The system and its environment can exchange heat and do work on each other through a boundary that separates them. However, the immediate surroundings of the system interact with it directly and therefore have a much stronger influence on its behavior and properties.
Consider an example of  tea boiling in a kettle. The...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reduced Atopic March Risk in Pediatric Atopic Dermatitis Patients Prescribed Dupilumab vs Conventional Immunomodulatory Therapy: A Population-Based Cohort Study.

Pediatrics·2025
Same author

Risk of Atopic Dermatitis and the Atopic March Paradigm in Children of Mothers With Atopic Illnesses: A Birth Cohort Study From the United Kingdom.

Pediatrics·2024
Same author

Atopic Dermatitis: Diagnosis, Disparity, and Management in Children of Color.

NASN school nurse (Print)·2023
Same author

Risk stratification of systemic reactions to subcutaneous immunotherapy: A retrospective study.

Allergy and asthma proceedings·2019
Same author

Utilization of high-fidelity simulation for medical student and resident education of allergic-immunologic emergencies.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2019
Same author

Educational and process improvements after a simulation-based anaphylaxis simulation workshop.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2016
Same journal

Therapeutic Targeting of the Bradykinin B2 Receptor in Immunological and Vascular Diseases: Insights from Kinin Biology to Clinical Outcomes.

Clinical reviews in allergy & immunology·2026
Same journal

β-blocker Therapy in Cholinergic Urticaria, Adrenergic Urticaria and the Aquagenic Continuum Beta-Blocker Therapy in Chronic Inducible Urticaria.

Clinical reviews in allergy & immunology·2026
Same journal

Immunopathogenesis and Cytokine Pathways in Reactive Infectious Mucocutaneous Eruption (RIME) in Pediatric Population: Infectious Triggers and Molecular Insights.

Clinical reviews in allergy & immunology·2026
Same journal

Neuropsychological Factors in Vitiligo: Mechanisms and Clinical Application.

Clinical reviews in allergy & immunology·2026
Same journal

Tertiary Lymphoid Structure: A Potential Therapeutic Target Affecting Immune Response in Autoimmune Diseases.

Clinical reviews in allergy & immunology·2026
Same journal

Differentiating Acute-onset Autoimmune Hepatitis From Drug-Induced Autoimmune-like Hepatitis: A Multicenter Study and Score Development.

Clinical reviews in allergy & immunology·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K

Systemic Contact Dermatitis.

Marcella Aquino1,2, Greg Rosner3

  • 1SUNY at Stony Brook, Stony Brook, NY, USA. marcella.aquino@nyulangone.org.

Clinical Reviews in Allergy & Immunology
|May 17, 2018
PubMed
Summary
This summary is machine-generated.

Systemic contact dermatitis (SCD) involves skin reactions to allergens via different exposure routes. Understanding its pathophysiology and diagnostic challenges is key for managing this condition effectively.

Keywords:
Avoidance dietsBaboon syndromePatch testSystemic contact dermatitis

More Related Videos

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.0K
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K

Related Experiment Videos

Last Updated: Feb 10, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.0K
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K

Area of Science:

  • Dermatology
  • Immunology
  • Allergology

Background:

  • Systemic contact dermatitis (SCD) is a skin reaction occurring through routes other than direct skin contact with a sensitizing allergen.
  • Allergens implicated include metals, medications, and foods, with pathophysiology possibly involving Type 4 and Type 3 hypersensitivity reactions.
  • The pharmacologic interaction with immunoreceptors (p-I) concept offers a potential explanation for first-time medication-induced SCD.

Purpose of the Study:

  • To elucidate the pathophysiology of Systemic Contact Dermatitis (SCD).
  • To clarify the nomenclature challenges and subcategories of SCD, such as Allergic Contact Dermatitis Syndrome (ACDS), Baboon syndrome, and Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE).
  • To discuss diagnostic methods and management strategies for SCD.

Main Methods:

  • Review of existing literature on SCD pathophysiology, clinical presentations, and diagnostic approaches.
  • Discussion of the p-I concept in relation to drug-induced SCD.
  • Analysis of the utility of patch testing (PT) for diagnosing SCD.

Main Results:

  • SCD pathophysiology appears mediated by hypersensitivity reactions, with the p-I concept potentially explaining reactions upon first exposure to drugs.
  • Nomenclature for SCD and its variants (ACDS, Baboon syndrome, SDRIFE) presents challenges due to overlapping features.
  • Patch testing is beneficial for diagnosing SCD caused by metals and various topical medications.

Conclusions:

  • Accurate diagnosis and management of SCD require understanding its complex pathophysiology and varied clinical presentations.
  • Identifying causative allergens, whether foods, metals, or medications, is crucial for effective treatment, alongside symptomatic relief.
  • Further research into SCD pathophysiology and standardized nomenclature is warranted.