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Published on: September 11, 2011
Patient willingness to undergo efavirenz dose reduction based on pharmacogenetic testing
Margaret Mitchell1, Caroline Wells2, Xuechao Zhang3
1Vanderbilt University, Nashville, TN, USA.
Aim:
Among HIV-infected adults receiving efavirenz fixed-dose combination tablets, genotyping could guide efavirenz dose reduction but would require more pills.
Methods:
We assessed willingness to dose reduce among 129 patients at an HIV primary care clinic in the southeastern USA.
Results:
When told that switching from one pill to two or three pills "might make you feel a little better", 47% expressed definite or possible willingness. This decreased to 9% if there was "a small chance it might not control your HIV as well". Clinical variables were not associated with willingness.
Conclusion:
Many patients receiving a fixed-dose combination tablet may be willing to take more pills in order to dose reduce, guided by genetic testing, but only if virologic control is not compromised.
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