Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fixed Action Patterns01:06

Fixed Action Patterns

17.7K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
Patterns of Fever01:26

Patterns of Fever

4.0K
Before understanding the types and patterns of fever, it is essential to know its phases.
4.0K
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

1.5K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.5K
¹H NMR Signal Multiplicity: Splitting Patterns01:13

¹H NMR Signal Multiplicity: Splitting Patterns

6.9K
When protons A and X are coupled, their nuclear spin energy levels are slightly modified. This is because the energy required to excite proton A to a spin state parallel to proton X is slightly different from the energy required for it to become anti-parallel to spin X. Consequently, there are two possible excitation frequencies for A (A1 and A2), depending on the spin state of X, and vice versa. The mutual nature of coupling implies that the difference between frequencies A1 and A2, indicated...
6.9K
Assessment of the Gastrointestinal System II: Health Perception Pattern01:29

Assessment of the Gastrointestinal System II: Health Perception Pattern

507
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
507
The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

39.0K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
39.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Co-option of an ancestral cloacal regulatory landscape during digit evolution.

Nature·2025
Same author

Establishment, conservation, and innovation of dorsal determination mechanisms during the evolution of vertebrate paired appendages.

bioRxiv : the preprint server for biology·2025
Same author

Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation.

Development (Cambridge, England)·2024
Same author

Genetic regulation of injury-induced heterotopic ossification in adult zebrafish.

Disease models & mechanisms·2024
Same author

Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation.

bioRxiv : the preprint server for biology·2024
Same author

Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues.

Development (Cambridge, England)·2024
Same journal

Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy.

eLife·2026
Same journal

Analysis of dendritic input currents during place field dynamics.

eLife·2026
Same journal

TopoMetry systematically learns and evaluates the latent geometry of single-cell data.

eLife·2026
Same journal

Navigating the path: Advice to physician-scientists on choosing a clinical specialty.

eLife·2026
Same journal

Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex.

eLife·2026
Same journal

The exquisite mechanics of a tsetse bite.

eLife·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

A Mouse Model of Lumbar Spine Instability
05:28

A Mouse Model of Lumbar Spine Instability

Published on: April 23, 2021

9.1K

Patterning the spine.

Matthew P Harris1,2, Gloria Arratia3

  • 1Department of Genetics, Harvard Medical School, Boston, United States.

Elife
|May 17, 2018
PubMed
Summary
This summary is machine-generated.

The notochord guides zebrafish spine development. This essential embryonic structure provides support and crucial developmental instructions for the forming spine.

Keywords:
Entpd5Notochorddevelopmental biologyevolutionsegmentation clocksomitestem cellsvertebraezebrafish

More Related Videos

Imaging Dendritic Spines in Caenorhabditis elegans
09:14

Imaging Dendritic Spines in Caenorhabditis elegans

Published on: September 27, 2021

2.8K
3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

7.4K

Related Experiment Videos

Last Updated: Feb 10, 2026

A Mouse Model of Lumbar Spine Instability
05:28

A Mouse Model of Lumbar Spine Instability

Published on: April 23, 2021

9.1K
Imaging Dendritic Spines in Caenorhabditis elegans
09:14

Imaging Dendritic Spines in Caenorhabditis elegans

Published on: September 27, 2021

2.8K
3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

7.4K

Area of Science:

  • Developmental biology
  • Chordate embryology
  • Zebrafish models

Background:

  • The notochord is a transient embryonic structure critical for development.
  • Understanding notochord function is key to deciphering spinal patterning.
  • Zebrafish offer a powerful model for studying vertebrate development.

Purpose of the Study:

  • To investigate the role of the notochord in zebrafish spine patterning.
  • To elucidate the mechanisms by which the notochord instructs spinal development.

Main Methods:

  • Utilized zebrafish as a model organism.
  • Employed genetic and imaging techniques to observe notochord-embryo interactions.
  • Analyzed gene expression patterns related to spinal development.

Main Results:

  • Confirmed the notochord's essential role in patterning the zebrafish spine.
  • Identified specific signaling pathways mediated by the notochord.
  • Demonstrated the notochord's instructive capacity during embryogenesis.

Conclusions:

  • The notochord is a fundamental organizer of vertebral column formation in zebrafish.
  • Further research into notochord signaling can inform treatments for spinal defects.