Related Experiment Video
Updated: Feb 10, 2026
11:19
Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets
Published on: July 7, 2010
15.0K
Gene regulation in the 3D genome
Yun Li1, Ming Hu2, Yin Shen3,4
1Department of Genetics, Department of Biostatistics, Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA.
Human Molecular Genetics
|May 17, 2018
Summary
Understanding genome 3D structure reveals how gene promoters communicate with enhancers. This spatial organization is key for gene regulation and offers insights into complex diseases.
Area of Science:
- Genomics
- Molecular Biology
- Epigenetics
Background:
- The 3D genome's spatial organization is crucial for precise gene expression control.
- Advances in sequencing and imaging technologies enable large-scale exploration of genome architecture and gene regulation.
Purpose of the Study:
- To review current knowledge on genome organization and chromatin folding in gene regulation.
- To discuss the implications of chromatin structure in communication between gene promoters and distal cis-regulatory elements like enhancers.
- To introduce models explaining how enhancers regulate target genes in the 3D genome.
Main Methods:
- Review of existing literature on genome organization.
- Survey of chromosome conformation capture (3C) technologies and their readouts.
- Discussion of emerging models for enhancer-gene communication.
Main Results:
- Chromatin folding plays a significant role in gene regulation.
- Communication between promoters and distal enhancers is facilitated by 3D genome organization.
- Emerging models provide insights into enhancer-mediated transcriptional control.
Conclusions:
- Knowledge of chromatin spatial organization is vital for understanding gene regulation.
- Leveraging insights into the 3D genome holds promise for studying complex diseases and traits.
Related Concept Videos
03:21Genome Size and the Evolution of New Genes
9.2K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.2K
03:21Genome Size and the Evolution of New Genes
3.5K
3.5K
02:02Genomics
40.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.9K
01:17Gene Regulation During Sporulation
518
Sporulation is a complex developmental process that allows certain Gram-positive bacteria, such as Bacillus subtilis and Clostridium species, to survive extreme environmental conditions. This process is tightly regulated by a series of signaling cascades and transcriptional controls, ensuring the formation of a highly resistant endospore.Sporulation is triggered by unfavorable conditions, such as nutrient depletion, and is governed by a phosphorelay system. One of the sensor kinases, such as...
518
02:30Genomic Imprinting and Inheritance
37.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.3K
01:46Epigenetic Regulation
33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K