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Meningitis caused by Salmonella enterica serotype Panama in Brazil: first case reported

Maria Regina Pires Carneiro1, Maria Iracema de Aguiar Patrício2, Sona Jain1

  • 1Departamento de Morfologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical
|May 17, 2018
PubMed

Insights

The first reported case of Salmonella Panama meningitis in a Brazilian newborn highlights a rare but severe infection. This Salmonella serotype can cause serious extra-intestinal illness in infants, requiring medical alertness.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pediatrics

Background:

  • Salmonella infections typically manifest as self-limiting gastroenteritis.
  • Certain Salmonella serotypes can lead to severe extra-intestinal infections, including bacteremia and meningitis.
  • Neonates are particularly vulnerable to severe Salmonella-related complications.

Observation:

  • A 4-month-old male infant in Brazil presented with meningitis.
  • The causative agent was identified as Salmonella Panama, marking the first reported case of this serotype causing meningitis in Brazil.
  • The isolated Salmonella Panama strain demonstrated susceptibility to all tested antimicrobial agents.

Findings:

  • Polymerase chain reaction (PCR) confirmed the presence of virulence genes agfA, fimA, invA, sfbA, phoP, and slyA in the S. Panama isolate.
  • Genetic analysis provides insights into the potential mechanisms of pathogenicity for this invasive strain.

Implications:

  • Physicians should maintain a high index of suspicion for Salmonella Panama meningitis in neonates presenting with meningitis symptoms.
  • Early recognition and appropriate management are crucial due to the potential for high mortality rates or recurrent infections associated with invasive Salmonella Panama.
  • This case underscores the importance of considering less common Salmonella serotypes in neonatal meningitis, especially in specific geographic regions.

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