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Engineering Alginate Membranes With Green Propolis-Coated Silver Nanoparticles for Potential Use in Wound Dressing
Erica Tirzah S Lima1, Victoria L S Santos1,2, Jad Lorena F Simplício2,3
1Institute of Research and Technology, University Tiradentes, Aracaju, Sergipe, Brazil.
Chemistry & Biodiversity
|July 6, 2026
Summary
This study developed novel polymeric wound dressings using sodium alginate, silver nanoparticles (AgNPs), and green propolis extract (GPE). The enhanced membranes show improved properties and biocompatibility for advanced wound care applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Advanced wound dressings require materials with antimicrobial properties, enhanced healing capabilities, and optimal physical characteristics.
- Sodium alginate is a biocompatible polymer, but its properties can be enhanced with functional additives for wound healing.
- Silver nanoparticles (AgNPs) and green propolis extract (GPE) are known for their antimicrobial and therapeutic effects.
Purpose of the Study:
- To develop and characterize novel polymeric membranes incorporating AgNPs and GPE for wound dressing applications.
- To evaluate the physical, mechanical, and thermal properties of the developed alginate-based membranes.
- To assess the biocompatibility and potential therapeutic efficacy of these advanced wound dressings.
Main Methods:
- Five formulations of sodium alginate membranes were prepared, including a control, GPE-only, and varying concentrations of AgNPs.
- Membrane characterization involved FT-IR, DSC, TGA/DTG, thickness measurements, water vapor permeability (WVP), mechanical testing (strain, Young's Modulus), and contact angle measurements.
- Biocompatibility was assessed using the chorioallantoic membrane (CAM) assay, and molecular docking was performed on key GPE compounds.
Main Results:
- Successful incorporation of GPE and AgNPs into the alginate matrix was confirmed, with increased membrane thickness and enhanced hydrophilicity.
- AgNP-containing membranes showed improved water vapor permeability (WVP) and enhanced flexibility (strain ~90%, Young's Modulus 0.29-0.32 MPa).
- The CAM assay confirmed a non-irritating profile, and molecular docking suggested therapeutic potential for wound care.
Conclusions:
- The novel alginate/AgNP/GPE membranes demonstrate promising properties for wound dressing applications.
- These advanced materials offer enhanced physical characteristics, biocompatibility, and potential antimicrobial benefits.
- Further research into these composite membranes could lead to improved wound healing outcomes.
