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A Rapid Image-based Bacterial Virulence Assay Using Amoeba
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Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

Christian S Lentz1, Jessica R Sheldon2, Lisa A Crawford3

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Nature Chemical Biology
|May 18, 2018
PubMed
Summary

Researchers identified novel Staphylococcus aureus serine hydrolases, including FphB, crucial for infection but not growth. Inhibiting FphB reduced bacterial infectivity, offering a potential therapeutic target for Staphylococcus infections.

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