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Updated: Feb 10, 2026

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Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
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What do we know about how to improve vaccine uptake?
1BC Centre for Disease Control and School of Population and Public Health, University of British Columbia, Vancouver, BC.
Summary
Understanding vaccine hesitancy is crucial for maintaining immunization success. Addressing factors like complacency, convenience, and confidence is key to public vaccine acceptance and uptake.
Area of Science:
- Public Health
- Immunization Science
- Health Behavior
Background:
- Vaccine uptake in Canada has evolved over 100 years, with initial focus on access barriers.
- Recent research highlights vaccine hesitancy, influenced by complacency, convenience, and confidence.
- Drivers of hesitancy include complex immunization schedules and increased health consumerism.
Purpose of the Study:
- To analyze the shift in vaccine research focus from access barriers to vaccine hesitancy.
- To identify key factors contributing to vaccine hesitancy in the current century.
- To underscore the importance of addressing vaccine hesitancy for future immunization success.
Main Methods:
- Literature review of vaccine uptake research trends over the past century.
- Analysis of factors influencing public demand and acceptance of vaccines.
- Identification of current drivers of vaccine hesitancy.
Main Results:
- Research focus shifted from access barriers in the 1990s to vaccine hesitancy in the 21st century.
- Complacency, convenience, and confidence are significant factors in vaccine hesitancy.
- Societal concerns regarding risk-benefit and health consumerism contribute to hesitancy.
Conclusions:
- Addressing vaccine hesitancy is critical to prevent undermining immunization program success.
- Practitioner and program-based resources are available to manage vaccine hesitancy.
- Further research is needed to fully understand and combat vaccine hesitancy.
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