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Tuberculosis drug resistance in Canada: 2006-2016
1Centre for Communicable Disease and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Summary
Tuberculosis (TB) drug resistance in Canada remained low and stable between 2006-2016. The Canadian Tuberculosis Laboratory Surveillance System (CTBLSS) monitors drug-resistant TB strains, finding no extensively drug-resistant TB (XDR-TB) cases in 2016.
Area of Science:
- Public Health
- Infectious Diseases
- Epidemiology
Background:
- Drug-resistant tuberculosis (TB) presents a significant challenge to global TB control.
- The Canadian Tuberculosis Laboratory Surveillance System (CTBLSS) was established in 1998 to track TB drug resistance trends in Canada.
Purpose of the Study:
- To provide a descriptive analysis of TB drug resistance data from the CTBLSS between 2006 and 2016.
- To focus specifically on the drug resistance patterns observed in Canada in 2016.
Main Methods:
- Utilized the CTBLSS, an isolate-based surveillance system for TB drug resistance data collection across Canada.
- Data were collected annually, analyzed by the Public Health Agency of Canada (PHAC), and validated by submitting laboratories.
Main Results:
- In 2016, 1,452 TB isolates were tested; 7.4% were monoresistant, 0.3% polyresistant, and 1.2% multidrug-resistant (MDR-TB).
- No extensively drug-resistant TB (XDR-TB) isolates were identified in 2016.
- Between 2006-2016, the 15-44 age group represented the majority of MDR-TB strains (72.3%).
Conclusions:
- TB drug resistance in Canada has remained low and stable over an 11-year period, below global averages.
- The CTBLSS is crucial for ongoing monitoring of TB drug resistance, especially given global concerns about MDR-TB and XDR-TB emergence.
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