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Related Concept Videos

Chirality02:25

Chirality

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Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
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Chirality in Nature02:30

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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

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Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
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Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
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Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”. 
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Metallic Solids02:37

Metallic Solids

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Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
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Related Experiment Video

Updated: Feb 10, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

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Chiral Recognition and Separation by Chirality-Enriched Metal-Organic Frameworks.

Saikat Das1, Shixian Xu1, Teng Ben1

  • 1Department of Chemistry, Jilin University, 130012, Changchun, China.

Angewandte Chemie (International Ed. in English)
|May 18, 2018
PubMed
Summary

This study introduces a cost-effective method for creating chiral metal-organic frameworks (MOFs) using inexpensive materials and recoverable chiral dopants. The resulting MOFs demonstrate efficient chiral separation capabilities, opening new avenues for enantioselective processes.

Keywords:
chiral inductionchiralityhost-guest complexesmetal-organic frameworksmixed-matrix membranes

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Area of Science:

  • Materials Science
  • Supramolecular Chemistry
  • Chiral Chemistry

Background:

  • Chiral metal-organic frameworks (MOFs) possess valuable chiral channels and pores for applications.
  • The synthesis of chiral MOFs is often hindered by the high cost of chiral building blocks.
  • Previous studies on induced chirality in MOFs lacked quantitative evidence of enantiomeric excess (ee).

Purpose of the Study:

  • To develop an efficient and cost-effective method for synthesizing chirality-enriched MOFs.
  • To investigate the use of inexpensive achiral building blocks and recoverable chiral dopants for MOF chirality induction.
  • To evaluate the chiral separation capabilities of the synthesized MOFs.

Main Methods:

  • Employing inexpensive achiral building blocks and fully recoverable chiral dopants to induce chirality in MOFs.
  • Synthesizing MOFs with controlled handedness and accessible pores.
  • Characterizing the host-guest complexation behavior of chirality-enriched MOFs with various enantiomers and solvents.
  • Fabricating mixed-matrix membranes (MMMs) using the MOF particles for chiral separation.

Main Results:

  • Successful induction of chirality in MOFs using a novel, cost-effective approach.
  • Obtained chirality-enriched MOFs with accessible pores suitable for host-guest interactions.
  • Demonstrated the ability of these MOFs to form host-guest complexes with enantiomers of varying sizes and coordination.
  • Validated the efficacy of MMMs incorporating these MOFs for chiral separation.

Conclusions:

  • This work presents the first quantitative evidence for efficient chiral induction in MOFs using inexpensive achiral precursors and recoverable chiral dopants.
  • The developed method provides a scalable and economical route to chiral MOFs with tunable properties.
  • The chirality-enriched MOFs show significant potential for advanced chiral separation technologies.