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Fertility, Pregnancy, and Clinical Outcomes after Uterine Arteriovenous Malformation Management
Sophie Delplanque1, Maela Le Lous1, Maïa Proisy2
1Department of Obstetrics and Gynecology Gynecology (Drs. Delplanque, Le Lous, Joueidi, Bauville, Levêque, Lavoué, and Timoh) and Radiology (Drs. Proisy, Bauville, Rozel, Beraud, and Bruneau), Rennes Hospital, Rennes University 1, Rennes, France; Université de Rennes 1 (Drs. Delplanque, Le Lous, Proisy, Joueidi, Levêque, Lavoué, and Timoh), Rennes, France.
Study Objective:
To evaluate fertility, pregnancy, and clinical outcomes after uterine arteriovenous malformation (UAVM) management.
Design:
Single-center retrospective study (Canadian Task Force classification III).
Setting:
One referral center.
Patients:
Twenty-two patients with a UAVM diagnosed by magnetic resonance angiography or computed tomography angiography and managed by expectant management (EM) or uterine arterial embolization (UAE) during the study period were included.
Interventions:
Nine of 22 patients underwent first-intention EM and 13 first-line UAE. Three of 9 EM patients (33.3%) required emergency second-intention UAE for nonresolution of the UAVM and severe genital bleeding.
Measurements And Main Results:
To analyze fertility according to management approach, we defined 2 groups: EM only group (n = 6) and UAE group (n = 16; women who underwent first- or second-intention UAE). Overall, the median age was 29 years (range, 17-43). The mean follow-up after UAVM management was 39 months (range, 1-116). The success rate of the UAE procedure was 87.5% (14/16). Eight of 12 women (66.7%) who wished to conceive became pregnant: 2 of 5 (33.3%) in the EM group and 6 of 7 (85.7%) in the UAE group (p = 1). Overall, 11 patients (50%) conceived: 3 in the EM group (50%) and 8 in the UAE group (50%) (p = .9). The live birth rate was 36.4% (8/22) for the whole population. There were no miscarriages or ectopic pregnancies. The 8 women (72.7%) wishing to conceive who became pregnant all delivered: 1 by cesarean section and 7 by vaginal delivery. Median duration of pregnancy was 39 weeks and 5 days. The remaining 3 women (i.e., women who conceived but did not wish to become pregnant) had therapeutic abortions. One complication was experienced in the EM group (small for gestational age newborn) and none in the UAE group (p = .3). Limitations include retrospective design and small sample size.
Conclusion:
UAE for UAVM is an effective and safe technique. It does not impair fertility, and obstetric prognosis is good.
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