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Published on: September 10, 2016
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Antibodies Against GPCR.
Carlotto Meyer1, Harald Heidecke2
1CellTrend GmbH, Im Biotechnologiepark TGZ II, 14943 Luckenwalde, Germany.
Frontiers in Bioscience (Landmark Edition)
|May 18, 2018
Summary
Auto-antibodies targeting G-protein-coupled receptors (GPCRs) can activate specific pathways, contributing to various diseases. This review explores the role of these activating anti-GPCR auto-antibodies in transplantation, autoimmune disorders, cardiovascular conditions, neurodegenerative diseases, and cancer.
Area of Science:
- Immunology
- Molecular Biology
- Pathophysiology
Background:
- G-protein-coupled receptors (GPCRs) are crucial cell surface receptors involved in numerous physiological processes.
- Auto-antibodies (aab) can bind to GPCRs, acting as ligands and modulating receptor activity.
- Dysregulated GPCR signaling by auto-antibodies is implicated in the pathogenesis of diverse diseases.
Purpose of the Study:
- To review current knowledge on antibodies targeting GPCRs.
- To elucidate the effects and relevance of anti-GPCR auto-antibodies in disease pathogenesis.
- To discuss the diagnostic and therapeutic potential of targeting GPCR-directed auto-antibodies.
Main Methods:
- Literature review of studies investigating auto-antibodies against GPCRs.
- Analysis of the role of activating anti-GPCR auto-antibodies in various clinical conditions.
- Synthesis of information on the clinical relevance and diagnostic applications.
Main Results:
- Activating anti-GPCR auto-antibodies play a significant role in conditions such as solid organ and stem cell transplantations.
- These auto-antibodies are implicated in systemic sclerosis, preeclampsia, chronic fatigue syndrome, cardiovascular diseases, Alzheimer's disease, and cancer.
- Specific cellular pathways are activated by distinct auto-antibodies targeting GPCRs.
Conclusions:
- Auto-antibodies targeting GPCRs represent a significant factor in the pathogenesis of a wide range of diseases.
- Understanding these interactions is crucial for developing novel diagnostic tools and therapeutic strategies.
- Targeting GPCR-directed auto-antibodies holds promise for clinical diagnostics and treatment across multiple medical fields.
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