Bioprostheses and its Alternative Fixation
Marc Hendriks1, Frank Everaerts1, Michel Verhoeven1
1Medtronic Bakken Research Center, Materials and Biosciences Center, Endepolsdomein 5, 6229 GW Maastricht, The Netherlands.
Abstract:
The glutaraldehyde fixation technique for bioprosthetic tissue valves has been used for about 30 years. It is more or less generally recognized, however, that a solution to the ongoing problems of calcification and immunomodulated inflammation can only be achieved with the development of alternative fixation techniques that differ from fixation with glutaraldehyde. This review reports on the chemistry behind newly developed tissue-fixation processes and the preliminary results achieved with these.
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