Related Experiment Video
Updated: Feb 10, 2026

A Possible Zebrafish Model of Polycystic Kidney Disease: Knockdown of wnt5a Causes Cysts in Zebrafish Kidneys
Published on: December 2, 2014
Dialysis modality and mortality in polycystic kidney disease
Chenchen Zhou1, Yaodong Gu1, Changlin Mei2
1Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Introduction:
Identifying the appropriate modality between hemodialysis (HD) and peritoneal dialysis (PD) is an unresolved issue in polycystic kidney disease (PKD) patients. This study aims to illustrate whether the mortality and survival are different among individuals receiving HD comparing PD.
Methods:
We searched PubMed, EMBASE, and China National Knowledge Infrastructure about cohort studies involving PKD patients with end stage renal disease and comparing HD with PD. We calculated pooled risk ratios (RRs) with 95% confidence intervals (CIs) for dichotomous data. Primary outcomes were the mortality and survival (not the technique survival).
Findings:
Eight studies involving 7685 PKD patients were identified. There were no significant differences in mortality (RR 1.06, 95% CI 0.84-1.34, P = 0.61) and 5-year survival rate (RR 0.99, 95% CI 0.80-1.22, P = 0.90) between HD and PD. PD was not associated with higher risks of abdominal infections and hernia. However, HD was associated with a higher incidence of renal cyst hemorrhage (RR 2.53, 95% CI 1.05-6.12, P = 0.04).
Discussion:
There are no significant differences of mortality and survival between different dialysis modalities in PKD. PD may be as successful as HD for PKD patients receiving renal replacement therapy.
More Related Videos
07:35Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
12:47Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
Published on: February 3, 2012
Related Concept Videos
Chronic Kidney Disease I: Introduction
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Dialysis
Chronic Kidney Disease II: Clinical Manifestations
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Chronic Kidney Disease III: Interprofessional Care