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Mouse Kidney Transplantation: Models of Allograft Rejection
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Genetic and genomic approaches to the detection of heart transplant rejection

Evan P Kransdorf1, Jon A Kobashigawa2

  • 1Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.

Personalized Medicine
|May 20, 2018
PubMed

Insights

Heart transplant rejection remains a major threat. Gene-expression testing offers a noninvasive method for monitoring rejection, improving allograft survival and patient outcomes in heart transplantation.

Area of Science:

  • Cardiology
  • Immunology
  • Transplant Science

Background:

  • Cardiac allograft rejection remains a primary challenge post-heart transplantation.
  • Endomyocardial biopsy is the standard for rejection monitoring but is invasive.
  • Over 100,000 heart transplants have been performed globally since 1967.

Purpose of the Study:

  • To review the pathological and clinical aspects of cardiac allograft rejection.
  • To discuss the development and application of gene-expression testing for rejection detection.
  • To explore future 'omic' approaches for rejection surveillance.

Main Methods:

  • Review of literature on cardiac allograft rejection.
  • Discussion of gene-expression profiling (e.g., AlloMap®) for noninvasive monitoring.
  • Exploration of emerging 'omic' technologies.

Main Results:

  • Gene-expression testing provides a noninvasive alternative to endomyocardial biopsy.
  • This technology aids in the management and surveillance of heart transplant recipients.
  • Emerging 'omic' methods show promise for future rejection detection.

Conclusions:

  • Noninvasive gene-expression testing is crucial for managing heart transplant recipients.
  • Continued innovation in 'omic' technologies will further enhance rejection detection.
  • Improved rejection surveillance strategies are vital for long-term allograft survival.

Keywords:
antibody-mediated rejectioncellular rejectionendomyocardial biopsygene-expression profilinggenomicsheart transplantationmycophenolate mofetilpharmacogenomicstacrolimus

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