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Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial
Tomohiro Sawa1, Katsuhiko Ono1, Hiroyasu Tsutsuki1
1Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Advances in Microbial Physiology
|May 21, 2018
Summary
Cysteine hydropersulphide (CysSSH) and related persulphides are biologically present and act as antioxidants. These sulfur compounds are crucial for redox signaling and protecting cells from oxidative damage.
Area of Science:
- Biochemistry
- Cell Biology
- Analytical Chemistry
Background:
- Persulphides, such as Cysteine hydropersulphide (CysSSH), are sulfur-containing molecules found in prokaryotes and eukaryotes.
- Recent analytical advancements enable detection and quantification of various persulphide forms, including glutathione and protein hydropersulphides.
Purpose of the Study:
- To review the biological occurrence and biosynthesis of CysSSH and related persulphides.
- To highlight recent analytical methods for persulphide detection.
- To discuss the antioxidant and signaling roles of persulphides.
Main Methods:
- Review of current literature on persulphide biology and analytical techniques.
- Discussion of established and emerging methods for persulphide quantification.
- Analysis of experimental data on persulphide antioxidant activity and signaling pathways.
Main Results:
- Persulphides are biologically prevalent and involved in synthesizing sulfur-containing biomolecules.
- Persulphides exhibit potent reducing activity, contributing to antioxidant defense against reactive oxygen species.
- CysSSH plays a significant role in bacterial redox signaling.
Conclusions:
- CysSSH and related persulphides are vital redox regulators with significant antioxidant functions.
- Further research into persulphide biochemistry and analytical methods is warranted.
- Persulphides are key players in cellular protection and signaling pathways.
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