Related Experiment Video
Updated: Feb 10, 2026

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability
Published on: July 25, 2025
Microendoscopy-Assisted Minimally Invasive Versus Open Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative
Yang Yang1, Zhong-Yu Liu1, Liang-Ming Zhang1
1Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Objective:
We sought to evaluate 5-year outcomes between microendoscopy-assisted minimally invasive (MIS) and open transforaminal lumbar interbody fusion (TLIF).
Methods:
Sixty single-level MIS and open surgeries were performed (30 patients in either group). Perioperative parameters including operative duration, intraoperative estimated blood loss, fluoroscopy time, postoperative analgesic usage, ambulatory time, and complications were recorded. Visual analog scale (back and leg), Japanese Orthopaedics Association score, and Oswestry Disability Index were obtained. Finally, self-evaluation of surgical outcomes (modified MacNab criteria), interbody fusion rate (Bridwell grade 1), and prevalence of adjacent segment degeneration were assessed.
Results:
Intraoperative estimated blood loss and postoperative analgesia usage were reduced in the MIS group, and patients undergoing microendoscopy-assisted MIS-TLIF ambulated earlier than those receiving open TLIF postoperatively. Nevertheless, surgical duration and fluoroscopy time were prolonged in the MIS group. Complication incidences were similar in both groups. Visual analog scale (back and leg), Japanese Orthopaedics Association, and Oswestry Disability Index were improved at 1 month, 2 years, and 5 years postoperatively in both groups when compared with preoperative scores. Significant improvements in these scores were found in the MIS group at 1 month postoperatively, while at 2 years and 5 years postoperatively, both groups revealed comparable aforementioned scores. Excellent and perfect scale rating, interbody fusion rate, and adjacent segment degeneration prevalence between the groups were almost similar.
Conclusions:
Microendoscopy-assisted MIS-TLIF is comparable with open TLIF in terms of 5-year outcomes with additional benefits of reduced intraoperative iatrogenic injury, decreased initial pain, minimized activity restrictions, and accelerated ambulation recovery after surgery.
Insights
Microendoscopy-assisted minimally invasive (MIS) transforaminal lumbar interbody fusion (TLIF) shows comparable 5-year outcomes to open TLIF. MIS-TLIF offers benefits like reduced injury and faster recovery, despite longer surgical times.
Area of Science:
- Spinal surgery
- Minimally invasive techniques
- Fusion procedures
Background:
- Transforaminal lumbar interbody fusion (TLIF) is a common spinal procedure.
- Minimally invasive surgery (MIS) aims to reduce surgical trauma.
- Microendoscopy offers enhanced visualization during MIS.
Purpose of the Study:
- To compare 5-year outcomes of microendoscopy-assisted MIS-TLIF versus open TLIF.
- To evaluate perioperative parameters and long-term functional results.
Main Methods:
- Sixty patients underwent single-level MIS or open TLIF (30 per group).
- Perioperative data, pain scores (VAS), functional scores (JOA, ODI), and fusion rates were assessed.
- Long-term outcomes included modified MacNab criteria and adjacent segment degeneration.
Main Results:
- MIS-TLIF showed reduced blood loss and earlier ambulation but longer operative time and fluoroscopy.
- Both groups improved significantly in pain and function scores at 5 years.
- Fusion rates and adjacent segment degeneration were similar between groups.
Conclusions:
- Microendoscopy-assisted MIS-TLIF is comparable to open TLIF at 5 years.
- MIS-TLIF provides benefits of less iatrogenic injury and quicker recovery.
- Long-term functional outcomes and fusion success are equivalent.
Related Concept Videos
Nuclear Fusion
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
5-Number Summary
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
Predicting Reaction Outcomes
Outcomes of Glycolysis
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Guidelines for Writing Outcome
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Tagging and Fusion Proteins

