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Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
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Correction to: Naturally occurring cell adhesion inhibitors.

Journal of natural medicines·2018
See all related articles

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Naturally occurring cell adhesion inhibitors.

Satoshi Takamatsu1

  • 1Division of Natural Medicine and Therapeutics, Department of Clinical Pharmacy, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan. stakamat@pharm.showa-u.ac.jp.

Journal of Natural Medicines
|May 21, 2018
PubMed
Summary

This review explores natural cell adhesion inhibitors from plants, microbes, and marine sources. It details their classification, effects on cell proliferation, and impact on cell adhesion.

Keywords:
Cell adhesionHUVECICAM-1InhibitorLFA-1LPSNatural productsPMATNF-α

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Cell adhesion is crucial in biological processes.
  • Dysregulated cell adhesion is implicated in various diseases.
  • Natural compounds offer potential therapeutic strategies for modulating cell adhesion.

Purpose of the Study:

  • To comprehensively review naturally occurring cell adhesion inhibitors.
  • To classify plant-derived inhibitors based on structural types.
  • To categorize microbially and marine-derived inhibitors by their discovery timeline.

Main Methods:

  • Literature review of scientific databases.
  • Systematic classification of identified inhibitors.
  • Compilation of data on inhibitor effects on cell proliferation.
  • Documentation of standard compound effects on cell adhesion.

Main Results:

  • Plant-derived inhibitors are categorized by distinct structural classes.
  • Microbial and marine inhibitors are presented chronologically.
  • Data on the impact of these inhibitors on cell proliferation is summarized.
  • Comparative effects of standard cell adhesion modulators are listed.

Conclusions:

  • Natural products represent a rich source of cell adhesion inhibitors.
  • Structural diversity exists among plant-derived inhibitors.
  • Temporal discovery trends are evident for microbial and marine sources.
  • Further research into these natural inhibitors may yield novel therapeutic agents.