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Naturally occurring cell adhesion inhibitors.

Journal of natural medicines·2018
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Correction to: Naturally occurring cell adhesion inhibitors.

Satoshi Takamatsu1

  • 1Division of Natural Medicine and Therapeutics, Department of Clinical Pharmacy, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan. stakamat@pharm.showa-u.ac.jp.

Journal of Natural Medicines
|August 5, 2018
PubMed
Summary

This study explores naturally occurring cell adhesion inhibitors. These compounds play a crucial role in biological processes and disease regulation.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Cell adhesion is fundamental to multicellular organisms.
  • Dysregulated cell adhesion is implicated in various diseases, including cancer and inflammation.
  • Identifying natural inhibitors of cell adhesion is a key area of research.

Purpose of the Study:

  • To review and synthesize current knowledge on naturally occurring cell adhesion inhibitors.
  • To discuss the mechanisms of action and potential therapeutic applications of these inhibitors.
  • To highlight gaps in current research and suggest future directions.

Main Methods:

  • Literature review of scientific databases (e.g., PubMed, Scopus).
  • Analysis of studies on natural products with cell adhesion inhibitory properties.
  • Categorization of inhibitors based on their source and mechanism.

Main Results:

  • Several classes of natural compounds exhibit significant cell adhesion inhibitory activity.
  • Inhibitors derived from plants, microorganisms, and marine organisms have been identified.
  • Mechanisms include interference with adhesion molecules (e.g., integrins, selectins) and signaling pathways.

Conclusions:

  • Naturally occurring cell adhesion inhibitors represent a promising source for therapeutic development.
  • Further research is needed to elucidate their precise mechanisms and optimize their efficacy and safety.
  • These compounds hold potential for treating diseases associated with aberrant cell adhesion.