Left ventricular structural and functional changes in young men at increased risk of developing essential

J R Nielsen1, H Oxhøj, J Fabricius

  • 1Department of Clinical Physiology, Odense University Hospital, Denmark.

Annals of Clinical Research
|January 1, 1988
PubMed

Insights

Young individuals at risk for high blood pressure may develop left ventricular hypertrophy (LVH), a structural heart change. This cardiac remodeling is linked to borderline hypertension in these at-risk subjects.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Investigation

Background:

  • Essential hypertension often develops in young adulthood.
  • Genetic predisposition and borderline hypertension are risk factors for cardiovascular changes.
  • Early detection of cardiac alterations in at-risk youth is crucial.

Purpose of the Study:

  • To determine if young individuals with an elevated risk for essential hypertension exhibit left ventricular structural changes.
  • To investigate the association between borderline hypertension and cardiac structural modifications in a young population.

Main Methods:

  • Study population included young normotensive and borderline hypertensive individuals.
  • Subjects were stratified based on parental history of hypertension.
  • Echocardiography or similar imaging techniques were likely used to assess left ventricular structure (details not provided in abstract).

Main Results:

  • Left ventricular hypertrophy (LVH) was identified in young subjects with increased risk for essential hypertension.
  • The presence of LVH was significantly associated with borderline hypertension in this cohort.

Conclusions:

  • Young individuals with risk factors for hypertension may already present with left ventricular hypertrophy.
  • Borderline hypertension in youth is linked to structural cardiac changes, specifically LVH.
  • These findings highlight the importance of monitoring cardiac health in young people at risk for hypertension.

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...