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Age differences in the neural response to negative feedback.

Holly J Bowen1, Cheryl L Grady2,3, Julia Spaniol4

  • 1a Department of Psychology , Boston College , Chestnut Hill , MA , USA.

Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
|May 22, 2018
PubMed
Summary
This summary is machine-generated.

Healthy aging preserves affective processing. While both young and older adults use similar brain networks for general feedback, older adults show unique neural activity for negative feedback, aligning with positivity theories.

Keywords:
AgingPLSfunctional covariancepositivity effectreward

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Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Affective Science

Background:

  • Affective processing is generally preserved in healthy aging.
  • Previous research shows similar midbrain reward region activation in older and younger adults, but differing recruitment based on incentive cue valence (gain/loss).

Purpose of the Study:

  • To investigate functional covariance during gain and loss feedback processing in younger and healthy older adults.
  • To identify age-related differences in neural network engagement during reward feedback.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to scan 15 older adults (mean age 68.5) and 16 younger adults (mean age 25.4).
  • Participants completed a revised Monetary Incentive Delay (rMID) task involving gain and loss anticipation cues and feedback.
  • Seed-voxel partial least squares analyses were conducted with seeds in the caudate and ventromedial prefrontal cortex.

Main Results:

  • Whole-brain functional covariance revealed that both age groups engage similar neural networks for general feedback processing.
  • Older adults uniquely engaged two additional networks for processing negative feedback outcomes (gain_miss, loss_miss, loss_hit).

Conclusions:

  • Findings suggest that while general feedback processing is conserved, older adults exhibit distinct neural responses to negative feedback.
  • These results support the positivity effect in aging and may impact reward-stimulus learning and decision-making after negative feedback.