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Nucleolar Function in Lifespan Regulation.

Varnesh Tiku1, Adam Antebi2

  • 1Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50931 Cologne, Germany; Present Address: Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Trends in Cell Biology
|May 22, 2018
PubMed
Summary
This summary is machine-generated.

The nucleolus, once thought to be just for ribosome production, plays key roles in organismal aging and diseases like cancer. This review explores its broader functions impacting aging.

Keywords:
aginglifespannucleolusnutrient sensing pathwaysribosome biogenesis

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Gerontology

Background:

  • The nucleolus is a key nuclear organelle traditionally linked to ribosomal RNA (rRNA) synthesis and ribosome assembly.
  • Emerging research indicates the nucleolus is involved in diverse cellular processes beyond ribosome biogenesis.
  • Dysfunctional nucleoli are implicated in diseases including cancer and progeria, and in development and aging.

Purpose of the Study:

  • To review the multifaceted roles of the nucleolus.
  • To highlight the nucleolus's impact on organismal aging.
  • To discuss recent findings on nucleolar functions in development and disease.

Main Methods:

  • Literature review of recent studies on nucleolar functions.
  • Analysis of evidence linking nucleolar perturbations to aging and disease.
  • Synthesis of current understanding of nucleolar roles in cellular physiology.

Main Results:

  • The nucleolus is crucial for numerous cellular processes affecting organismal physiology.
  • Nucleolar dysfunction is associated with aging, cancer, and progeria.
  • The nucleolus significantly influences development and the aging process.

Conclusions:

  • The nucleolus is a vital cellular hub with functions extending far beyond ribosome biogenesis.
  • Understanding nucleolar functions is critical for addressing age-related diseases and cellular aging.
  • Further research into the nucleolus promises insights into health, disease, and longevity.