Related Experiment Video

Updated: Feb 10, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

14.4K

Iterative Synthesis of Polydeoxypropionates Based on Iridium-Catalyzed Asymmetric Hydrogenation of α-Substituted

Wen Che, Danyang C Wen, Shou-Fei Zhu

    Organic Letters
    |May 22, 2018
    PubMed

    More Related Videos

    Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction11:17

    Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

    Published on: January 19, 2016

    23.2K
    Asymmetric Thermoelectrochemical Cell for Harvesting Low-grade Heat under Isothermal Operation09:09

    Asymmetric Thermoelectrochemical Cell for Harvesting Low-grade Heat under Isothermal Operation

    Published on: February 5, 2020

    7.7K

    Related Concept Videos

    Acid-Catalyzed α-Halogenation of Aldehydes and Ketones01:21

    Acid-Catalyzed α-Halogenation of Aldehydes and Ketones

    By replacing an α-hydrogen with a halogen, acid-catalyzed α-halogenation of aldehydes or ketones yields a monohalogenated product
    In the first step of the mechanism, the acid protonates the carbonyl oxygen resulting in a resonance-stabilized cation, which subsequently loses an α-hydrogen to form an enol tautomer. The C=C bond in an enol is highly nucleophilic because of the electron-donating nature of the –OH group. Consequently, the double bond attacks an electrophilic halogen to form a...
    4.9K
    Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction01:26

    Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

    α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.
    4.2K
    Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

    Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

    Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
    The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
    3.9K
    Acid-Catalyzed Ring-Opening of Epoxides02:24

    Acid-Catalyzed Ring-Opening of Epoxides

    Epoxides that are three-membered ring systems are more reactive than other cyclic and acyclic ethers. The high reactivity of epoxides originates from the strain present in the ring. This ring strain acts as a driving force for epoxides to undergo ring-opening reactions either with halogen acids or weak nucleophiles in the presence of mild acid. The acid catalyst converts the epoxide oxygen, a poor leaving group, into an oxonium ion, a better leaving group, making the reaction feasible. The...
    9.0K
    Lewis Acids and Bases02:33

    Lewis Acids and Bases

    In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
    A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
    48.5K
    Acid-Catalyzed Hydration of Alkenes02:45

    Acid-Catalyzed Hydration of Alkenes

    Alkenes react with water in the presence of an acid to form an alcohol. In the absence of acid, hydration of alkenes does not occur at a significant rate, and the acid is not consumed in the reaction. Therefore, alkene hydration is an acid-catalyzed reaction.
    17.4K