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[Response predictors for physical training HFrEF patients]
V L Galenko1, T A Lelyavina1, M Y Sitnikova1
1Federal State Budgetary Institution "Federal Almazov North-West Medical Research Center" of the Ministry of Health of the Russian Federation.
Kardiologiia
|May 22, 2018
Summary
Physical rehabilitation significantly improves heart function and exercise capacity in heart failure patients. Higher baseline VO2 peak, sodium, and hemoglobin predict better outcomes, aiding personalized treatment strategies.
Area of Science:
- Cardiology
- Rehabilitation Medicine
- Exercise Physiology
Background:
- Reduced ejection fraction heart failure (HFrEF) significantly impacts quality of life and exercise capacity.
- Identifying predictors of response to physical rehabilitation (PR) is crucial for optimizing HFrEF management.
Purpose of the Study:
- To identify response types and predictors of PR in HFrEF patients who achieved lactate threshold during cardiopulmonary exercise testing (CPET).
Main Methods:
- 64 NYHA II-III HFrEF patients underwent PR. Data included physical examination, labs, CPET, quality of life (QOL), exercise tolerance (ET), and echocardiography (EchoCG).
- PR efficiency assessed by VO2peak, QOL, ET (1, 3, 6 months), and ejection fraction (EF) (6 months).
- Statistical analysis performed using "Statistika, 9.0" software.
Main Results:
- After 6 months, PR improved EF (+7.5%), QOL (+17.5 pts), ET (+9.5 pts), and VO2 peak (+4.4 ml/min/kg).
- Significant improvements observed in EF (48%), VO2 peak (64%), QOL (64%), and ET (67%) of patients.
- Strong positive correlations found between baseline VO2 peak and EF (r=0.4), and between sodium/hemoglobin and PR efficiency (r=0.41/0.45, p<0.05).
Conclusions:
- PR is effective in improving cardiac function, exercise capacity, and QOL in selected HFrEF patients.
- Baseline VO2 peak, sodium, and hemoglobin levels are significant predictors of PR response.
- These findings support tailored PR programs for HFrEF patients based on individual characteristics.
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