[EFFECT OF CITOFLAVIN ON THE PARAMETERS OF LIPID PEROXIDATION IN BLOOD PLASMA OF RATS UNDER COLD STRESS CONDITIONS.]

Area of Science:

• Biochemistry
• Physiology
• Pharmacology

Background:

• Cold exposure induces oxidative stress, increasing lipid peroxidation.
• Antioxidant system activity is diminished during prolonged cold stress.

Purpose of the Study:

• To investigate the efficacy of cytoflavin in mitigating cold-induced oxidative damage.
• To assess cytoflavin's impact on lipid peroxidation and antioxidant system markers.

Main Methods:

• Experimental study involving rats subjected to daily cold exposure.
• Administration of cytoflavin (100 mg/kg, i.p.) prior to cold stress.
• Measurement of lipid hydroperoxides, diene conjugates, malonic dialdehyde, ceruloplasmin, and vitamin E levels.

Main Results:

• Cytoflavin significantly reduced levels of lipid hydroperoxides, diene conjugates, and malonic dialdehyde.
• Administration of cytoflavin led to a significant increase in ceruloplasmin and vitamin E levels.
• These effects were observed on the background of increased activity of the blood antioxidant system.

Conclusions:

• Cytoflavin effectively corrects free radical oxidation of lipid membranes under cold stress conditions.
• The compound stabilizes lipid peroxidation processes and enhances antioxidant system activity in vivo.