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Biomarkers for development of cancer vaccines
Mike Whelan1,2,3,4, Graham Ball1,2,3,4, Chris Beattie1,2,3,4
1St George's Hospital Medical School, Onyvax Ltd, Cranmer Terrace, London, SW17 0RE, UK. mwhelan@onyvax.com.
Abstract:
The search for molecules that correlate with cancer progression is an evolving and exciting area of research. Such biomarkers have utility in a number of areas, most notably in a variety of clinical development programs. Modern technologies are revealing multiple potential biomarker candidates. However, the challenge remains in validating the correlation in levels of a particular molecule with clinical parameters. In this article, the area of biomarkers and cancer vaccines is briefly reviewed and the possibility of combining multiple molecules to generate a profile that correlates with outcome, rather than using more conventional single molecule biomarker systems, is explored.
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