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Updated: Sep 1, 2026

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
14:05

A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction

Published on: December 20, 2014

Abdominal wall defects and obstructive uropathies. Aetiology and management

K C Pringle1

  • 1Department of Surgery, Wellington School of Medicine, New Zealand.

Fetal Therapy
|January 1, 1988
PubMed

Insights

Gastroschisis and omphalocele are distinct birth defects with unique anomalies. Management strategies for these conditions, including delivery and in utero interventions for associated renal dysplasia, are discussed, highlighting the need for further research.

Area of Science:

  • Developmental biology
  • Perinatal medicine
  • Pediatric surgery

Background:

  • Gastroschisis and omphalocele are distinct congenital abdominal wall defects.
  • Each condition presents with a unique set of associated anomalies.
  • Current literature presents controversies regarding optimal perinatal management and antenatal diagnosis.

Purpose of the Study:

  • To review and discuss the perinatal management of gastroschisis and omphalocele.
  • To explore controversies surrounding the etiology of renal dysplasia and its association with urinary tract obstruction.
  • To outline therapeutic options and indications for in utero shunting procedures.

Main Methods:

  • Literature review and synthesis of existing research on gastroschisis and omphalocele.
  • Discussion of controversies in perinatal management, delivery modes, and antenatal diagnosis.
  • Analysis of etiological factors and treatment options for renal dysplasia, including in utero interventions.

Main Results:

  • Gastroschisis and omphalocele, though both abdominal wall defects, are embryologically distinct.
  • Management strategies address controversies in delivery methods and antenatal diagnosis.
  • The etiology of renal dysplasia and the utility of in utero shunting remain areas of debate.

Conclusions:

  • Emphasizes the need for prospective randomized trials to resolve management controversies.
  • Highlights the challenges in selecting appropriate indices for treatment decisions in trials.
  • Stresses the importance of long-term follow-up for all patients in such trials.

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