Related Experiment Video

Updated: Feb 10, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.1K

Efficacy and safety of rituximab in relapsing and progressive multiple sclerosis: a hospital-based study

Carmen Alcalá1, F Gascón2, F Pérez-Miralles3

  • 1Unit of Neuroimmunology, Department of Neurology, Hospital Universitari i Politècnic La Fe, 106 Avenue Fernando Abril Martorell, 46026, Valencia, Spain. mc.alcalavicente@gmail.com.

Journal of Neurology
|May 23, 2018
PubMed
Abstract

Insights

Rituximab significantly reduced relapse rates and disease progression in multiple sclerosis (MS) patients. This B-cell depleting therapy demonstrated effectiveness and safety in both relapsing-remitting MS and selected progressive MS cases.

Area of Science:

  • Neuroimmunology
  • Clinical Neurology
  • Pharmacology

Background:

  • Rituximab is a potential therapeutic option for relapsing-remitting multiple sclerosis (RRMS) and progressive multiple sclerosis (PMS).
  • Assessing rituximab's efficacy and safety in MS is crucial for treatment decisions.

Purpose of the Study:

  • To evaluate the clinical and radiological effectiveness of rituximab in MS patients.
  • To assess the safety profile of rituximab treatment in RRMS and PMS.

Main Methods:

  • Observational study design.
  • Included 90 patients with RRMS (31) and PMS (59) with active disease despite standard treatments.
  • Collected data on annualized relapse rate (ARR), gadolinium-enhanced lesions, and Expanded Disability Status Scale (EDSS).

Main Results:

  • Rituximab reduced ARR by 88.4% (p < 0.001) and EDSS significantly decreased to 4.6 (p = 0.01) after one year.
  • 70% of patients showed no evidence of disease activity (74.2% RRMS, 67% PMS).
  • Most common side effect was mild infusion-related symptoms (18.8%); three thrombotic events occurred.

Conclusions:

  • Rituximab is an effective and safe treatment for aggressive RRMS.
  • Selected PMS patients may also benefit from rituximab therapy.
Keywords:
Anti-CD20 monoclonal antibodyMultiple sclerosisProgressive multiple sclerosisRelapsing-remitting multiple sclerosisRituximabTreatment

More Related Videos

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.8K
Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis08:11

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Published on: November 14, 2016

11.6K

Related Concept Videos

Hospitals-II00:59

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...
1.2K
Hospitals-I01:28

Hospitals-I

Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.7K
Survey Safety01:28

Survey Safety

Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
413
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
251
Self-Efficacy01:29

Self-Efficacy

Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
234
Household Wiring And Electrical Safety01:13

Household Wiring And Electrical Safety

Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.7K