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A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput
Published on: September 22, 2019
A convergent strategy towards febrifugine and related compounds
T M M Maiden1, N Mbelesi, P A Procopiou
1Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK. j.harrity@Sheffield.ac.uk.
Abstract:
We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.
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