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MicroRNAs as potential regulators of platelet function and bleeding diatheses

Ascensión M De Los Reyes-García1, Ana B Arroyo1, Raúl Teruel-Montoya1,2

  • 1Department of Hematology and Medical Oncology, Morales Meseguer University Hospital, Centro Regional de Hemodonación, University of Murcia, IMIB-Arrixaca , Murcia , Spain.

Platelets
|May 23, 2018
PubMed

Insights

MicroRNAs (miRNAs) are increasingly linked to platelet function and bleeding disorders. This review explores how platelet miRNAs influence hemostasis and their potential role in immune thrombocytopenia (ITP).

Area of Science:

  • Hematology
  • Molecular Biology
  • Genetics

Background:

  • Platelet biology is increasingly understood to involve microRNAs (miRNAs).
  • Alterations in platelet miRNA levels are linked to thrombotic phenotypes.
  • Immune thrombocytopenia (ITP) is a primary acquired bleeding disorder associated with altered miRNA levels.

Purpose of the Study:

  • To review the role of miRNAs in platelet hemostatic and thrombotic functions.
  • To discuss the association between miRNAs and the regulatory mechanisms of immune thrombocytopenia (ITP).

Main Methods:

  • Literature review of studies on miRNAs, platelet function, and bleeding disorders.
  • Analysis of research linking miRNA alterations to thrombotic phenotypes.
  • Examination of studies associating miRNAs with primary immune thrombocytopenia (ITP).

Main Results:

  • Platelet miRNAs significantly impact hemostatic and thrombotic processes.
  • Altered intracellular levels of highly expressed platelet miRNAs can lead to a thrombotic state.
  • Evidence suggests a connection between altered miRNA levels in various biological samples and ITP.

Conclusions:

  • MicroRNAs are critical regulators of platelet function with implications for bleeding diatheses.
  • Further investigation into miRNA regulatory mechanisms in ITP is warranted.
  • Targeting specific miRNAs may offer new therapeutic strategies for ITP and other bleeding disorders.
Keywords:
MicroRNAsbleedingimmune thrombocytopeniaplatelet function

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