Related Experiment Video
Updated: Feb 10, 2026
05:51
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
26.5K
Lower P300 amplitudes for internally-generated events in patients with schizophrenia
Priyadarshee Abhishek1, S Haque Nizamie2, Indu Dubey3
1Department of Clinical Psychology, LGBRIMH, Tezpur, Assam, 784001, India.
Asian Journal of Psychiatry
|May 23, 2018
Summary
Patients with schizophrenia show reduced P300 amplitude for internally-generated events, indicating impaired source monitoring. This suggests less attention to self-generated information, leading to misattribution.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Psychiatry
Background:
- Schizophrenia patients struggle to distinguish internal from external event origins.
- This difficulty may stem from excessive attention to external stimuli and poor processing of self-generated events.
Purpose of the Study:
- To investigate the neurophysiological underpinnings of source monitoring deficits in schizophrenia.
- To examine electrophysiological differences in processing internally versus externally generated information.
Main Methods:
- Seventeen schizophrenia patients and 14 healthy controls performed a source monitoring task.
- Electroencephalography (EEG) recorded brain activity, focusing on P300 amplitude and latency during internal source monitoring (ISM) and external source monitoring (ESM).
Main Results:
- Schizophrenia patients exhibited lower P300 amplitude for ISM compared to controls in parietal regions.
- Patients showed lower P300 amplitude for ISM versus ESM, while ESM did not differ between groups.
- No significant differences in P300 latency were observed within or between groups for either condition.
Conclusions:
- Reduced P300 amplitude for internally-generated events in schizophrenia patients suggests impaired source monitoring.
- Findings indicate diminished attentional resources allocated to internal events, leading to poorer processing and source misattribution.
- This study provides electrophysiological evidence for impaired source monitoring in schizophrenia.
More Related Videos
08:24The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
Published on: August 25, 2023
1.2K
11:01Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
14.1K
Related Concept Videos
01:17Schizophrenia
1.0K
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.0K
01:29Biological Causes of Schizophrenia
648
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
648
01:17Pulse amplitude and quality
3.2K
Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
3.2K
02:00Internal Energy
36.8K
The total of all possible kinds of energy present in a substance is called the internal energy (U), sometimes symbolized as E. Suppose a system with initial internal energy, Uinitial, undergoes a change in energy (transfer of work or heat), and the final internal energy of the system is Ufinal. Change in internal energy equals the difference between Ufinal and Uinitial.
36.8K
01:29Psychological and Sociocultural Causes of Schizophrenia
642
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
642
01:31Internal Receptors
74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K