Related Experiment Video

Updated: Feb 10, 2026

Calcified Artery Preparation and Processing with Preserved Morphology and RNA for Digital Spatial Profiling
09:12

Calcified Artery Preparation and Processing with Preserved Morphology and RNA for Digital Spatial Profiling

Published on: January 23, 2026

2.7K

Rotational Atherectomy in Acute STEMI with Heavily Calcified Culprit Lesion is a Rule Breaking Solution

Mohammady Shahin1, Alessandro Candreva1, Patrick T Siegrist1

  • 1Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland.

Current Cardiology Reviews
|May 24, 2018
PubMed

Insights

Rotational atherectomy successfully treated severely calcified lesions in a ST-elevation Myocardial Infarction (STEMI) patient, improving procedural outcomes. This approach facilitated stent delivery and revascularization in a challenging acute coronary syndrome case.

Area of Science:

  • Interventional Cardiology
  • Cardiovascular Interventions

Background:

  • Severely calcified coronary lesions pose significant challenges during percutaneous coronary intervention (PCI), often leading to restenosis and target lesion revascularization.
  • Rotational atherectomy is a valuable tool for managing calcified lesions, enhancing procedural success, stent deployment, and expansion.
  • Historically, rotational atherectomy has been contraindicated in ST-elevation Myocardial Infarction (STEMI) due to concerns of slow-flow or no-reflow phenomena and the presence of thrombus.

Observation:

  • A case study involving a patient experiencing acute anterior STEMI with persistent chest pain.
  • The patient presented with heavily calcified culprit lesions requiring intervention.

Findings:

  • Rotational atherectomy was successfully employed to facilitate lesion dilation and subsequent revascularization.
  • The procedure enabled successful stent delivery and expansion in the heavily calcified lesion.

Implications:

  • This case suggests that rotational atherectomy can be a safe and effective option for managing heavily calcified lesions in acute STEMI.
  • Successful application of rotational atherectomy in this STEMI case may broaden its use in complex coronary interventions.
  • Further investigation into the safety and efficacy of rotational atherectomy in STEMI patients with calcified lesions is warranted.
Abstract

Keywords:
Rotational atherectomySTEMITLRcalcified culprit lesionchest painthrombus.

More Related Videos

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K
Sectioning Mammary Gland Whole Mounts for Lesion Identification09:22

Sectioning Mammary Gland Whole Mounts for Lesion Identification

Published on: July 24, 2017

11.2K

Related Concept Videos

Exceptions to the Octet Rule02:55

Exceptions to the Octet Rule

Many covalent molecules have central atoms that do not have eight electrons in their Lewis structures. These molecules fall into three categories:
37.8K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.8K
Lewis Symbols and the Octet Rule02:36

Lewis Symbols and the Octet Rule

Chemical bonds are complex interactions between two or more atoms or ions, which reduce the potential energy of the molecule. Gilbert N. Lewis developed a model called the Lewis model that simplified the depiction of chemical bond formation and provided straightforward explanations for the chemical bonds seen in most common compounds.
81.7K
The Aufbau Principle and Hund's Rule03:02

The Aufbau Principle and Hund's Rule

To determine the electron configuration for any particular atom, we can build the structures in the order of atomic numbers. Beginning with hydrogen, and continuing across the periods of the periodic table, we add one proton at a time to the nucleus and one electron to the proper subshell until we have described the electron configurations of all the elements. This procedure is called the aufbau principle, from the German word aufbau (“to build up”). Each added electron occupies the...
73.7K
Determining the pH of Salt Solutions04:08

Determining the pH of Salt Solutions

The pH of a salt solution is determined by its component anions and cations. Salts that contain pH-neutral anions and the hydronium ion-producing cations form a solution with a pH less than 7. For example, in ammonium nitrate (NH4NO3) solution, NO3− ions do not react with water whereas NH4+ ions produce the hydronium ions resulting in the acidic solution.  In contrast, salts that contain pH-neutral cations and the hydroxide ion-producing anions form a solution with a pH greater than 7. For...
48.2K
Midpoint Rule01:20

Midpoint Rule

Approximating areas under curved boundaries is a common problem in applied mathematics, particularly when an exact calculation is difficult or impractical. One effective numerical method for this purpose is the Midpoint Rule, which provides an estimate of the area under a curve by using rectangular approximations over a specified interval.Description of the Midpoint RuleThe Midpoint Rule begins by dividing the given interval into a number of equal subintervals. For each subinterval, the...
71