Related Experiment Video
Updated: Feb 10, 2026
14:36
Isolation and Culture of Chick Ciliary Ganglion Neurons
Published on: August 8, 2020
6.4K
The Developmental Process of the Growing Motile Ciliary Tip Region
Matthew J Reynolds1,2, Tanaporn Phetruen1,3, Rebecca L Fisher1
1Wadsworth Center, New York State Department of Health, Albany, NY, 12201, USA.
Scientific Reports
|May 24, 2018
Summary
This study reveals that motile cilia undergo distinct morphological changes during development, even after reaching full length. The flagellar tip complex (FTC) leads cilium growth, suggesting it may not directly regulate intraflagellar transport (IFT).
Area of Science:
- Cell Biology
- Molecular Biology
- Developmental Biology
Background:
- Eukaryotic motile cilia and flagella are crucial for physiological functions in mammals and protists.
- Cilia formation defects lead to human disorders known as ciliopathies.
- The precise mechanisms of cilia growth and development remain incompletely understood.
Purpose of the Study:
- To characterize the process of cilium formation (ciliogenesis) in newly developed motile cilia.
- To investigate the morphological changes and structural dynamics during cilia growth.
Main Methods:
- Utilized complementary techniques including electron microscopy and advanced image analysis.
- Studied newly developed motile cilia in deciliated protists.
Main Results:
- Demonstrated progressive, time-dependent morphological changes in the distal tip region of motile cilia during development.
- Observed that these developmental changes continue even after cilia reach their full length.
- Structural analysis revealed that the flagellar tip complex (FTC) leads the ciliary tip, with B-tubules terminating before the tip.
Conclusions:
- The flagellar tip complex (FTC) plays a leading role in cilia tip structure and growth.
- Findings suggest the FTC may not be directly involved in the rapid turnover of intraflagellar transport (IFT).
Related Concept Videos
01:05Mechanism of Ciliary Motion
5.2K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
5.2K
01:27Introduction to Developmental Psychology
1.7K
Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...
1.7K
01:29Three Developmental Domains
1.2K
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
1.2K
01:03IR Frequency Region: Fingerprint Region
2.0K
IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
2.0K
01:16Gastric Motility
3.2K
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
3.2K
02:40The Eukaryotic Promoter Region
18.9K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.9K